Modelling and simulation of a diffusion limited glucose biosensor
Modelling and simulation of a diffusion limited glucose biosensor
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DOI：
10.1016/0925-4005(96)80099-2
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发表时间：
1996-07-01
影响因子：
8.4
通讯作者：
Vadgama, P
中科院分区：
文献类型：
--
作者：
Cambiaso, A;Delfino, L;Vadgama, P
电流型酶传感器的数学模型被描述为设计葡萄糖生物传感器的工具，在扩散限制方案中操作。这种酶电极实际上包括一个微型反应器系统，而不是经典形式的传感器。考虑到在一般情况下（非伪稳态）的扩散过程和酶促反应，得到的方程组成的模型。该模型的数值积分，以获得电极电流的时间行为。从模拟中得到了整个体系的米氏表观常数（K-mapp），并与体相体系的计算结果进行了比较。
A mathematical model for an amperometric enzyme sensor is described as a tool to design glucose biosensors, operating in a diffusion limited regimen. This kind of enzyme electrode really comprises a miniature reactor system rather than a classical form of transducer. The equations constituting the model are obtained taking into account both the diffusion process and the enzymatic reaction in the general (not pseudo-stationary) case. The model is numerically integrated in order to obtain the time behaviour of the electrode current. The Michaelis-Menten apparent constant (K-m app) of the whole system is obtained from the simulation and compared with that computed for a bulk system.