Observation and quantification of gas bubble formation on a mechanical heart valve
Observation and quantification of gas bubble formation on a mechanical heart valve
复制标题
DOI：
10.1115/1.1287171
复制
发表时间：
2000-08-01
影响因子：
1.7
通讯作者：
Tarbell, JM
中科院分区：
文献类型：
--
作者：
Lin, HY;Bianccucci, BA;Tarbell, JM
在机械心脏瓣膜（MHV）患者中使用经颅多普勒超声的临床研究检测到了气体栓塞。气栓释放和空化与MHV的关系一直是文献中争论的主题。为了研究空化和气体含量对稳定气泡形成和生长的影响，使用了在二尖瓣位置使用ct Medtronic-Hall热解碳圆盘阀的模拟循环回路。高速摄像机允许观察作为空化强度和二氧化碳（CO2）浓度函数的流入阀表面上的空化和气泡释放，而超声监测系统扫描主动脉流出道，通过计算图像的灰度级来量化气泡产生。在没有空化的情况下，没有形成稳定的气泡。当气泡形成时，它们首先在空化崩溃后几毫秒和附近被看到。随着CO2增加和空化强度增加，在主动脉通道检测到的气泡体积增加。未观察到O-2浓度与气泡体积之间的相关性。我们的结论是，空化是一个重要的前体稳定的气泡形成，和CO2，最可溶的血液气体，是稳定的气泡的主要成分。【S0148-0731（00）00204-1】。
Clinical studies using transcranial Doppler ultrasonography in patients with mechanical heart valves (MHV) have detected gaseous emboli. The relationship of gaseous emboli release and cavitation an MHV has been a subject of debate in the literature. To study the influence of cavitation and gas content on the formulation and growth of stable gas bubbles, a mock circulatory loop, which employed ct Medtronic-Hall pyrolytic carbon disk valve in the mitral position, was used. A high-speed video camera allowed observation of cavitation and gas bubble release on the inflow valve surfaces as a function of cavitation intensity and carbon dioxide (CO2) concentration, while an ultrasonic monitoring system scanned the aortic outflow tract to quantify gas bubble production by calculating the gray scale levels of the images. In the absence of cavitation, no stable gas bubbles were formed. When gas bubbles were formed, they were first seen a few milliseconds after and in the vicinity of cavitation collapse. The volume of the gees bubbles detected bl the aortic track increased with both increased CO2 and increased cavitation intensity. No correlation was observed between O-2 concentration and bubble volume. We conclude that cavitation is an essential precursor to stable gas bubble formation, and CO2, the most soluble blood gas, is the major component of stable gas bubbles. [S0148-0731(00)00204-1].