INTRAMOLECULAR DIELS-ALDER REACTIONS OF 1,2-DIAZINES - GENERAL INDOLINE SYNTHESIS - STUDIES ON THE PREPARATION OF THE CENTRAL AND RIGHT-HAND SEGMENTS OF CC-1065
INTRAMOLECULAR DIELS-ALDER REACTIONS OF 1,2-DIAZINES - GENERAL INDOLINE SYNTHESIS - STUDIES ON THE PREPARATION OF THE CENTRAL AND RIGHT-HAND SEGMENTS OF CC-1065
复制标题
DOI：
10.1021/jo00186a032
复制
发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
COLEMAN, RS
中科院分区：
文献类型：
--
作者：
BOGER, DL;COLEMAN, RS
研究了1，2-二氮杂环内的Diels-Alder反应及其在吲哚类化合物合成中的应用。详细介绍了这种环加成反应在1，2-二氢-~3H-吡咯并[3，2，-e]吲哚骨架的区域特异性制备中的应用，这是抗肿瘤抗生素CC-1065特有的结构亚基。
An investigation of the intramolecular Diels-Alder reaction of 1,2-diazines and the application of this cycloaddition to a general synthesis of indolines are described. The use of this cycloaddition in a short, regiospecific preparation of the 1,2-dihydro-3H-pyrrolo[3,2,-e]indole skeleton, the structural subunit characteristic of the antitumor antibiotic CC-1065, is detailed.