Early Life Origins of Obesity: Role of Hypothalamic Programming
Early Life Origins of Obesity: Role of Hypothalamic Programming
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DOI：
10.1097/mpg.0b013e3181977375
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发表时间：
2009-03-01
影响因子：
2.9
通讯作者：
Bouret, Sebastien G.
中科院分区：
文献类型：
--
作者：
Bouret, Sebastien G.
肥胖症的发病率正在以惊人的速度增加，这种全球流行病预示着 2 型糖尿病和代谢综合征等疾病的增加。流行病学和动物研究表明，母亲肥胖和产后营养的改变与后代肥胖、高血压和 2 型糖尿病的风险增加有关。此外，人们也越来越认识到，围产期环境对神经内分泌系统的发育编程是这些疾病的可能原因。这篇综述文章综合了有关围产期激素和营养在调节体重和能量平衡的下丘脑回路的发育和组织中的作用的最新证据。特别关注胰岛素和瘦素的神经发育作用。 JPGN 48：S31-S38，2009。
The incidence of obesity is increasing at an alarming rate and this worldwide epidemic represents an ominous predictor of increases in diseases such as type 2 diabetes and metabolic syndrome. Epidemiological and animals studies suggest that maternal obesity and alterations in postnatal nutrition are associated with increased risks for obesity, hypertension, and type 2 diabetes in the offspring. Furthermore, there is also growing appreciation that developmental programming of neuroendocrine systems by the perinatal environment represents a possible cause for these diseases. This review article provides a synthesis of recent evidence concerning the actions of perinatal hormones and nutrition in programming the development and organization of hypothalamic circuits that regulate body weight and energy balance. Particular attention is given to the neurodevelopmental actions of insulin and leptin. JPGN 48:S31-S38, 2009.