The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
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DOI：
10.1016/s1074-7613(00)80092-8
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发表时间：
1999-08-01
期刊：
影响因子：
32.4
通讯作者：
Surh, CD
中科院分区：
文献类型：
--
作者：
Ernst, B;Lee, DS;Surh, CD
对自身MHC/肽复合物的正选择长期以来被视为使T细胞库偏向于识别由自身MHC分子呈递的外源肽的装置。在这里，我们提供了另一种可能性的证据，即，在胸腺中的自我肽控制的积极选择，以维持外周成熟T细胞的寿命。令人惊讶的是，当总T细胞数量减少时，这些自身配体变得明显刺激，并导致幼稚T细胞增殖和经历稳态扩增。
Positive selection to self-MHC/peptide complexes has long been Viewed as a device for skewing the T cell repertoire toward recognition of foreign peptides presented by self-MHC molecules. Here, we provide evidence for an alternative possibility, namely, that the self-peptides controlling positive selection in the thymus serve to maintain the longevity of mature T cells in the periphery. Surprisingly, when total T cell numbers are reduced, these self-ligands become overtly stimulatory and cause naive T cells to proliferate and undergo homeostatic expansion.