Habituation of sympathetic-adrenal medullary responses following exposure to chronic intermittent stress.
Habituation of sympathetic-adrenal medullary responses following exposure to chronic intermittent stress.
复制标题
暴露于慢性间歇性应激后交感肾上腺髓质反应的习惯。
DOI：
10.1016/0031-9384(89)90127-3
复制
发表时间：
1989
影响因子：
2.9
通讯作者：
McCarty,R
中科院分区：
文献类型：
--
作者：
Konarska,M;Stewart,RE;McCarty,R
两项实验检测了连续26天每天短暂应激刺激后实验室大鼠的交感-肾上腺髓质反应。在第一个实验中，大鼠每天受到约束应激30分钟，在第二个实验中，大鼠每天受到不可避免的足震10分钟。在每个实验中，处理过的对照组被急性应激，以提供与慢性应激动物比较的基础。在这两项实验中，长期处于压力下的大鼠体重增长都低于对照组。在对照组和慢性应激大鼠中，去甲肾上腺素（NE）和肾上腺素（EPI）的基础血浆水平相似。然而，与急性应激对照相比，血浆儿茶酚胺对第27次约束或足部休克的反应有明显的衰减。这些发现表明，交感-肾上腺髓质反应在暴露于高度可预测的慢性间歇性应激方案的动物中受到相当大的抑制。
Two experiments examined sympathetic-adrenal medullary responses of laboratory rats after exposure to a brief period of stressful stimulation daily for 26 consecutive days. In the first experiment, rats were exposed to restraint stress for 30 minutes per day and in the second experiment, rats were exposed to inescapable footshock for 10 minutes per day. For each experiment, handled controls were stressed acutely to provide a basis for comparison with chronically stressed animals. In both experiments, chronically stressed rats gained less weight than controls. Basal plasma levels of norepinephrine (NE) and epinephrine (EPI) were similar in control and chronically stressed rats. However, there was a substantial attenuation of the plasma catecholamine response to the 27th episode of restraint or footshock compared to acutely stressed controls. These findings indicate that sympathetic-adrenal medullary responses are dampened considerably in animals exposed to a highly predictable regimen of chronic intermittent stress.