Activation of the amelanotic melanocytes in the outer root sheath of the hair follicle following ultra violet rays exposure.
Activation of the amelanotic melanocytes in the outer root sheath of the hair follicle following ultra violet rays exposure.
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紫外线照射后毛囊外根鞘中的无色素细胞被激活。
DOI：
10.1038/jid.1962.97
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发表时间：
1962
期刊：
影响因子：
--
通讯作者：
A. MILLER
中科院分区：
文献类型：
--
作者：
R. Staricco;A. MILLER
在人毛囊外根鞘的中部存在无黑素形式的黑素细胞，这一点以前已经被我们描述和讨论过（1，2，3）。克韦多和伊舍伍德发现，局部应用溶于苯的甲基胆蒽可激活兔子毛发中的”前体黑色素细胞”，他们指出刺激性化学刺激可能是这种激活的原因（4）。其他刺激物似乎也有可能产生这种激活作用。在此基础上，我们将一名25岁皮肤白皙的白色男性胸部有毛的区域暴露于每日递增剂量的紫外线（Hanovia Alpine），持续10天，并在第11天对治疗区域和邻近未暴露区域进行活检标本。通过溴化钠法从两个活检标本中获得皮肤分裂的唾液酸盐，然后用多巴处理（5）。观察：在照射区域，多巴-
The presence of an amelanotic form of melanocyte located in the middle portion of the outer root sheath of the human hair follicle has previously been described and discussed by one of us (1, 2, 3). Activation of" precursor melanocytes" in the hair of rabbits by the local application of methyl-cholanthrene in benzene was obtained by Quevedo and Isherwood who indicated the irritating chemical stimulus as the possible cause of such activation (4). It seemed possible that other stimuli would be capable of such activation. On the basis of such premises we exposed a well-defined hairy area of the chest of a 25 year old, fair-complected white male, to a daily erythem-atous dose of ultraviolet rays (Hanovia Alpine) in a gradually increasing amount for ten days, taking a biopsy specimen of the treated area and of an adjacent unexposed area on the 11th day. Skin-split preparates were obtained from both biopsy specimens by the sodium bromide method and were thereafter treated with dopa (5). Observation: In the irradiated area, dopa-