Quality and completeness of diagnoses recorded in the new CPRD Aurum Database: evaluation of pulmonary embolism
Quality and completeness of diagnoses recorded in the new CPRD Aurum Database: evaluation of pulmonary embolism
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DOI：
10.1002/pds.4996
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发表时间：
2020-03-28
影响因子：
2.6
通讯作者：
Myles, Puja
中科院分区：
文献类型：
--
作者：
Jick, Susan S.;Hagberg, Katrina Wilcox;Myles, Puja
临床实践研究数据链（CPRD）现在提供了一个新的医疗记录数据库，CPRD Aurum。这是第一个正在进行的几项研究，以评估的质量和完整性的CPRD金的数据research efforts.Methods我们确定了患者的肺栓塞（PE）诊断从随机抽样的50 000例CPRD金，并比较了诊断使用的数据从医院发作统计（HES）。我们计算了CPRD Aurum中记录的PE病例比例，这些病例也在HES中记录了PE诊断。我们还评估了完整性，确定所有PE诊断在HES和计算的比例也存在于CPRD Aurum.Results研究包括781 PE患者：580有一个PE在CPRD Aurum，632有一个PE在HES，和431有一个PE在这两个。经HES证实，CPRD Aurum中发生抗凝PE的患者比例为76.8%。与CPRD Aurum相比，主要住院PE HES事件的完整性为79.1%。在大多数情况下，有一个合理的解释，在两个datasource.Conclusions的PE的存在，本研究的结果是令人放心的，并建议在CPRD金诊断信息的正确性（例如，质量，准确性）和完整性是有前途的严重急性条件，需要医疗照顾。对其他数据元素的评估将为这种新的数据资源及其在医学研究中的效用提供更多的见解。
Purpose The Clinical Practice Research Datalink (CPRD) now provides a new medical record database, CPRD Aurum. This is the first of several studies being undertaken to assess the quality and completeness of CPRD Aurum data for research endeavors.Methods We identified patients with a pulmonary embolism (PE) diagnosis from a random sample of 50 000 patients in CPRD Aurum and compared the diagnoses using data from Hospital Episode Statistics (HES). We calculated the proportion of PE cases recorded in CPRD Aurum who also had a PE diagnosis recorded in HES. We also evaluated completeness by identifying all PE diagnoses in HES and calculating the proportion also present in CPRD Aurum.Results The study included 781 PE patients: 580 had a PE in CPRD Aurum, 632 had a PE in HES, and 431 had a PE in both. The proportion of patients with anticoagulated PE in CPRD Aurum confirmed by HES was 76.8%. The completeness of primary hospitalized PE HES events compared to CPRD Aurum was 79.1%. In most instances, there was a plausible explanation for the presence of a PE in only one of the two data sources.Conclusions The results of this study are reassuring and suggest that the correctness (eg, quality, accuracy) and completeness of diagnosis information in CPRD Aurum are promising with respect to serious acute conditions that require medical attention. Evaluation of other data elements will provide additional insight into this new data resource and its utility for medical research.