Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer.
Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer.
复制标题
DOI：
10.1155/2012/950508
复制
发表时间：
2012
影响因子：
2.3
通讯作者：
Marian B
中科院分区：
文献类型：
--
作者：
Holzmann K;Grunt T;Heinzle C;Sampl S;Steinhoff H;Reichmann N;Kleiter M;Hauck M;Marian B
成纤维细胞生长因子受体（FGFR）1-3的IgIII环的选择性剪接产生受体的B-和c-变体，其基于其不同的配体结合谱而具有明显不同的生物学影响。这些剪接变体的组织特异性表达调节胚胎发育、组织维护和修复以及癌症中的相互作用。FGFR 2剪接的改变涉及上皮间质转化，其在肿瘤进展期间产生侵袭性、转移性特征。 最近的研究已经阐明了在外源信号事件水平和RNA-蛋白质相互作用水平上决定剪接选择的调节因子。此外，已经开发了能够深入分析肿瘤发生过程中剪接事件的方法，并进一步了解FGFR 1-3 IIIb和IIIc在各种恶性肿瘤的病理生理学中的作用。本文旨在总结各种肿瘤类型中的表达模式，并概述进一步分析和应用的可能性。
Alternative splicing of the IgIII loop of fibroblast growth factor receptors (FGFRs) 1–3 produces b- and c-variants of the receptors with distinctly different biological impact based on their distinct ligand-binding spectrum. Tissue-specific expression of these splice variants regulates interactions in embryonic development, tissue maintenance and repair, and cancer. Alterations in FGFR2 splicing are involved in epithelial mesenchymal transition that produces invasive, metastatic features during tumor progression. Recent research has elucidated regulatory factors that determine the splice choice both on the level of exogenous signaling events and on the RNA-protein interaction level. Moreover, methodology has been developed that will enable the in depth analysis of splicing events during tumorigenesis and provide further insight on the role of FGFR 1–3 IIIb and IIIc in the pathophysiology of various malignancies. This paper aims to summarize expression patterns in various tumor types and outlines possibilities for further analysis and application.