Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis.
Posttranslational regulation of tissue inhibitor of metalloproteinase-1 by calcium-dependent vesicular exocytosis.
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DOI：
10.1002/phy2.125
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发表时间：
2013-11
影响因子：
2.5
通讯作者：
Sheung, Nina
中科院分区：
文献类型：
--
作者：
Dranoff, Jonathan A;Bhatia, Neal;Fausther, Michel;Lavoie, Elise G;Granell, Susana;Baldini, Giulia;Hickman, Dashawn A;Sheung, Nina
Liver myofibroblasts derived from hepatic stellate cells (HSC) are critical mediators of liver fibrosis. Release of tissue inhibitor of metalloproteinase-1 (TIMP-1) advances liver fibrosis by blocking fibrinolysis. The mechanisms responsible for the posttranslational regulation of TIMP-1 by myofibroblastic HSC are unknown. Here, we demonstrate that TIMP-1 release by HSC is regulated in a posttranslational fashion via calcium-sensitive vesicular exocytosis. To our knowledge, this is the first article to directly examine vesicular trafficking in myofibroblastic HSC, potentially providing a new target to treat and or prevent liver fibrosis.
