Novel isonahocol E3 exhibits anti-inflammatory and anti-angiogenic effects in endothelin-1-stimulated human keratinocytes.
Novel isonahocol E3 exhibits anti-inflammatory and anti-angiogenic effects in endothelin-1-stimulated human keratinocytes.
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新型 isonahocol E3 在内皮素 1 刺激的人角质形成细胞中表现出抗炎和抗血管生成作用。
DOI：
10.1016/j.ejphar.2013.09.077
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发表时间：
2013
影响因子：
5
通讯作者：
Tae
中科院分区：
文献类型：
--
作者：
S. Sah;Byung;G. Park;Sunghwan Kim;Kyoung Hwa Jang;Ju Eun Jeon;Jongheon Shin;Tae
内皮素-1 （ET-1）是一种有效的促有丝分裂和促血管生成因子，在生理和病理过程中都起着至关重要的作用。ET-1参与真皮细胞增殖和皮肤疾病，如牛皮癣和特应性皮炎。ET-1、内皮素eta受体和内皮素eta受体可能是开发特异性治疗此类疾病的潜在靶点。在这里，我们首次报道了褐藻esarg假设siliquastruma中的异纳hocol[2，-5-二羟基-3-（13-羟基-3，-7,-11，-15-四甲基-12-氧-十六-2，-6，-14-三烯基）-苯基]-乙酸甲酯（异纳hocol E3）对ET-1诱导的炎症和促血管生成作用具有功能性拮抗活性。异萘酚e3显著抑制et -1诱导的细胞增殖，以及永生化人角质形成细胞中白细胞介素-6 （IL-6）、白细胞介素-8 （IL-8）、肿瘤坏死因子-α (TNF-α)等炎症介质和金属蛋白酶等促血管生成因子。我们还发现异烟碱醇e3降低了内皮素eta受体和内皮素etb受体的表达水平，并抑制了et -1诱导的细胞外信号调节激酶（ERK）磷酸化。综上所述，我们的研究结果表明异烟碱醇e3至少通过调节ET-1受体的表达和ERK信号通路发挥抗炎和抗血管生成活性。
Endothelin-1 (ET-1) is reported to be a potent mitogenic and pro-angiogenic factor that plays a vital role in both physiological and pathological processes. ET-1 is implicated in dermal cell proliferation and skin disorders, such as psoriasis and atopic dermatitis. ET-1, endothelin ETAreceptor, and endothelin ETBreceptor could be potential targets for developing specific therapeutics to treat such disorders. Here, we provide the first report that an isonahocol [2,-5-dihydroxy-3-(13-hydroxy-3,-7,-11,-15-tetramethyl-12-oxo-hexadeca-2,-6,-14-trienyl)-phenyl]-acetic acid methyl ester (isonahocol E3) from the brown algaeSargassumsiliquastrumhas functional antagonistic activities against ET-1 induced inflammatory and pro-angiogenic effects. Isonahocol E3significantly inhibited ET-1-induced cell proliferation, as well as inflammatory mediators, such as interleukin-6 (IL-6) and interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α), and pro-angiogenic factors including metalloproteinases in immortalized human keratinocytes. We also found that isonahocol E3reduced expression level of endothelin ETAreceptor, and endothelin ETBreceptor as well as suppressed ET-1-induced extracellular signal-regulated kinase (ERK) phosphorylation. Taken together, our results suggest that isonahocol E3can exert anti-inflammatory and anti-angiogenic activities at least by regulating the expression of ET-1 receptors and ERK signaling pathway.
DOI：
10.1165/ajrcmb.16.5.9160841
发表时间：
1997-05-01
影响因子：
6.4
作者：
Whelchel, A;Evans, J;Posada, J
通讯作者：
Posada, J
Endothelin-1 是一种旁分泌生长因子，可调节人类黑素细胞的黑素生成并参与其对紫外线辐射的反应。
DOI：
--
发表时间：
1998
期刊：
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
影响因子：
--
作者：
Tada,A;Suzuki,I;Im,S;Davis,MB;Cornelius,J;Babcock,G;Nordlund,JJ;Abdel-Malek,ZA
通讯作者：
Abdel-Malek,ZA
Endothelin-1 促进气道平滑肌细胞有丝分裂。
DOI：
10.1165/ajrcmb.10.3.7509612
发表时间：
1994
影响因子：
6.4
作者：
Glassberg,MK;Ergul,A;Wanner,A;Puett,D
通讯作者：
Puett,D