Nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease
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DOI：
10.1503/cmaj.1050114
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发表时间：
2005-09
影响因子：
14.6
通讯作者：
L. Adams;P. Angulo;K. Lindor
中科院分区：
文献类型：
--
作者：
L. Adams;P. Angulo;K. Lindor
非酒精性脂肪肝是西方世界最常见的慢性肝病。它与胰岛素抵抗有关，经常发生代谢综合征的特征。疾病表现包括无症状的肝酶水平升高至肝硬化伴肝衰竭和肝细胞癌并发症。目前的治疗建议仅限于减肥和锻炼，尽管有几种有前途的药物即将问世。本文就非酒精性脂肪性肝病的病因、发病机制、诊断及治疗方法进行讨论。
Nonalcoholic fatty liver disease is emerging as the most common chronic liver condition in the Western world. It is associated with insulin resistance and frequently occurs with features of the metabolic syndrome. Disease presentation ranges from asymptomatic elevated liver enzyme levels to cirrhosis with complications of liver failure and hepatocellular carcinoma. Current treatment recommendations are limited to weight loss and exercise, although several promising medications are on the horizon. In this article we discuss the etiology, pathogenesis and diagnosis of nonalcoholic fatty liver disease as well as approaches to its management.