Comparison of Continuous Epidural Infusion of Fentanyl‐Bupivacaine and Morphine‐Bupivacaine in Management of Postoperative Pain
Comparison of Continuous Epidural Infusion of Fentanyl‐Bupivacaine and Morphine‐Bupivacaine in Management of Postoperative Pain
复制标题
连续硬膜外输注芬太尼布比卡因与吗啡布比卡因治疗术后疼痛的比较
DOI：
10.1213/00000539-198806000-00011
复制
发表时间：
1988
影响因子：
5.7
通讯作者：
A. Ivankovich
中科院分区：
文献类型：
--
作者：
R. L. Fischer;T. Lubenow;A. Liceaga;R. McCarthy;A. Ivankovich
硬膜外芬太尼持续时间短，限制了其与硬膜外吗啡的直接比较。对剖宫产患者进行术后连续硬膜外输注5 ml/hr芬太尼10 pg/ml （n = 59）或吗啡0.1 mg/ml (n = 48)，均加0.1%布比卡因。术后评估包括24小时内临床明显呼吸抑制的频率和程度、镇痛是否充分、恶心、瘙痒、行走能力和其他副作用。两组患者的镇痛效果和需要补充麻醉注射的次数相似。服用芬太尼的患者恶心和瘙痒的发生率明显减少。两组均无患者出现呼吸抑制。患者和工作人员对持续硬膜外技术的接受程度非常好，因为在使用硬膜外技术时只有轻微的导管相关问题。结论：连续硬膜外芬太尼联合布比卡因具有良好的术后镇痛效果，且副作用最小。
The short duration of epidural fentanyl has limited its direct comparison with epidural morphine in previous reports. The following study was performed of continuous postoperative epiduralinfusions at 5 ml/hr fentanyl 10 pg/ml (n = 59) or morphine 0.1 mg/ml (n = 48), both with bupivacaine 0.1%, in patients having cesarean sections. Postoperative evaluations included the frequency and magnitude of clinically evident respiratory depression, the adequacy of analgesia, nausea, pruritis, the ability to ambulate, and other side effects for 24 hours. Analgesia and the number of supplemental narcotic injections needed were similar in both groups. The incidence of nausea and pruritis was significantly less in the patients receiving fentanyl. No patient developed respiratory depression in either group. Patient and staff acceptance of the continuous epidural technique was excellent because there were only minor catheter-related problems associated with its use. It is concluded that continuous epidural fentanyl combined with bupivacaine offers excellent postoperative analgesia with minimal side effects.