High expression of an N-acetylglucosaminyltransferase III in 3'-methyl DAB-induced hepatoma and ascites hepatoma.

High expression of an N-acetylglucosaminyltransferase III in 3'-methyl DAB-induced hepatoma and ascites hepatoma.
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N-乙酰氨基葡萄糖转移酶 III 在 3-甲基 DAB 诱导的肝癌和腹水肝癌中高表达。

DOI:
10.1016/s0006-291x(88)80686-7
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发表时间:
1988
影响因子:
3.1
通讯作者:
Naoyuki Taniguchi
Naoyuki Taniguchi
中科院分区:
生物学4区
文献类型:
--
作者:
Atsushi Nishikawa;Shigeru Fujii;Toshihiro Sugiyama;N. Hayashi;Naoyuki Taniguchi

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AH-66和3‘-Me-DAE诱发的大鼠腹水型肝癌中含有高活性的N-乙酰氨基葡萄糖基转移酶III(GnT-III),该酶催化N-乙酰氨基葡萄糖通过β1-4连接(将N-乙酰氨基葡萄糖一分为二)加到天冬酰胺连接的糖链的甘露醇核心的β连接的甘露糖上,而正常大鼠肝脏中的GnT-III含量很少。在胎鼠肝、新生大鼠肝、增生性结节和各种可移植肝癌中也检测到高活性。
Ascites hepatoma AH-66 and 3′-Me-DAE-induced hepatoma of rats contain highly active N-acetylglucosaminyltransferase III (GnT-III) which catalyzes the addition of N-acetylglucosamine through a β1-4 linkage (bisecting N-acetylglucosamine) to the β-linked mannose of the trimannosyl core of asparagine-linked sugar chains, whereas normal rat liver contains very little. The high activity was also detected in fetal rat liver, newborn rat liver, hyperplastic nodules and various transplantable hepatomas.
乳清酸促进大鼠肝癌发生过程中肝结节中N-乙酰氨基葡萄糖转移酶III的表达。
DOI: --
发表时间: 1988
期刊: The Journal of biological chemistry
影响因子: --
作者:
Narasimhan,S;Schachter,H;Rajalakshmi,S
通讯作者: Rajalakshmi,S