The fruitless gene affects female receptivity and species isolation
The fruitless gene affects female receptivity and species isolation
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DOI：
10.1098/rspb.2019.2765
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发表时间：
2020-03-25
影响因子：
4.7
通讯作者：
Moehring, Amanda J.
中科院分区：
文献类型：
--
作者：
Chowdhury, Tabashir;Calhoun, Ryan M.;Moehring, Amanda J.
雌性配偶排斥是物种内的一种主要选择力，也是物种间的生殖障碍。尽管它在健康和繁殖中起着关键作用，但令人惊讶的是，人们对女性择偶变异的遗传或神经基础知之甚少。在这里，我们确定fruitless作为一个基因，影响雌性果蝇内的感受性，以及雌性果蝇simulans拒绝男性D。黑腹菌在该基因产生的多种转录本中，迄今为止研究最广泛的是参与性别决定途径的性别特异性剪接转录本。然而，我们发现，女性的排斥行为受到非性别特异性剪接无果的转录。这是女性行为中无结果的第一个含义，也是第一个确定无结果的非性别特异性剪接转录本的行为作用。我们发现，这个位点不影响偏好通过一个单一的感官形式，检查求爱歌曲，触角信息素的感知，或感知基板振动，我们得出结论，无果影响择偶通过整合多种信号或通过另一种感官形式。
Female mate rejection acts as a major selective force within species, and can serve as a reproductive barrier between species. In spite of its critical role in fitness and reproduction, surprisingly little is known about the genetic or neural basis of variation in female mate choice. Here, we identify fruitless as a gene affecting female receptivity within Drosophila melanogaster, as well as female Drosophila simulans rejection of male D. melanogaster. Of the multiple transcripts this gene produces, by far the most widely studied is the sex-specifically spliced transcript involved in the sex determination pathway. However, we find that female rejection behaviour is affected by a non-sex-specifically spliced fruitless transcript. This is the first implication of fruitless in female behaviour, and the first behavioural role identified for a fruitless non-sex-specifically spliced transcript. We found that this locus does not influence preferences via a single sensory modality, examining courtship song, antennal pheromone perception, or perception of substrate vibrations, and we conclude that fruitless influences mate choice via the integration of multiple signals or through another sensory modality.