PSMA7 inhibits the tumorigenicity of A549 human lung adenocarcinoma cells
PSMA7 inhibits the tumorigenicity of A549 human lung adenocarcinoma cells
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PSMA7抑制人肺腺癌细胞A549的致瘤性
DOI：
10.1007/s11010-012-1290-2
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发表时间：
2012-07-01
影响因子：
4.3
通讯作者：
Luo, Ya-Ling
中科院分区：
文献类型：
--
作者：
Tan, Jia-Yu;Huang, Xiang;Luo, Ya-Ling
蛋白酶体亚单位α -7型（PSMA7）的基因位于染色体20q13.33，这是肿瘤中经常扩增的区域。本研究以A549人肺腺癌细胞为实验对象，发现PSMA7在体外抑制A549细胞的增殖、致瘤性和侵袭性。此外，获得和丧失功能的研究表明，PSMA7在异种移植裸鼠模型中调节A549细胞的致瘤性。总之，这些结果确定了PSMA7与A549细胞致瘤性相关的抑制作用，提示PSMA7可能是一种潜在的肿瘤生物标志物。
The gene for proteasome subunit alpha type-7 (PSMA7) is located in chromosomal 20q13.33, a region frequently amplified in tumor. In this study, we employed A549 human lung adenocarcinoma cells and showed that PSMA7 inhibits the proliferation, tumorigenicity and invasion of A549 cells in vitro. Moreover, both gain and loss of function studies demonstrated that PSMA7 modulates the tumorigenicity of A549 cells in a xenograft nude mice model. In conclusion, these results identify inhibitory effects associated with PSMA7 that affect the tumorigenicity of A549 cells, suggesting PSMA7 as a potential tumor biomarker.