Aspirin, platelets, and thrombosis: theory and practice.
Aspirin, platelets, and thrombosis: theory and practice.
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DOI：
10.1182/blood.v83.4.885.bloodjournal834885
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发表时间：
1994
期刊：
影响因子：
20.3
通讯作者：
Gerald;Roth;D. Calverley
中科院分区：
文献类型：
--
作者：
Gerald;Roth;D. Calverley
“D OES阿司匹林预防心脏病发作？”病人和医生都问过这个问题，他们想知道头痛药如何影响致命的血管事件。今天，大量的证据表明，阿司匹林确实可以预防心脏病发作和相关的血栓性疾病，如中风。相关研究进行了二十多年，从临床流行病学到分子生物学，包括观察到阿司匹林通过与血小板α的酶的单一特异性反应发挥其抗血栓形成作用。这篇综述追溯了阿司匹林、血小板酶（环氧合酶）和血栓形成的临床数据之间的联系，并指出了这种独特药物的适应症、剂量和风险等问题。
“D OES ASPIRIN PREVENT heart attacks?” The question is asked by both patients and physicians who wonder how a pill for headaches could influence a lethal vascular event. Today, a wealth of evidence shows that aspirin does, indeed, prevent heart attacks and related thrombotic disorders such as strokes.’ Performed over more than two decades, the pertinent studies range from clinical epidemiology to molecular biology and include the observation that aspirin exerts its antithrombotic effect through a single specific reaction with an enzyme of blood platelet^.'^^ This review traces the connection between aspirin, the platelet enzyme (cyclo-oxygenase), and the clinical data on thrombosis, noting issues such as the indications, doses, and risks of this unique medication.