Antimony resistance associated with persistence of Leishmania (Leishmania) infantum infection in macrophages.
Antimony resistance associated with persistence of Leishmania (Leishmania) infantum infection in macrophages.
复制标题
锑抗性与巨噬细胞中婴儿利什曼原虫（Leishmania）感染的持续存在相关。
DOI：
10.1007/s00436-021-07231-7
复制
发表时间：
2021
影响因子：
2
通讯作者：
deMoura,TatianaRodrigues
中科院分区：
文献类型：
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作者：
Magalhães,LucasSousa;Bomfim,LaysGiseleSantos;Santos,CamillaNatáliaOliveira;DosSantos,PriscilaLima;Tanajura,DiegoMoura;Lipscomb,MichaelWheeler;deJesus,AméliaRibeiro;deAlmeida,RoquePacheco;deMoura,TatianaRodrigues
内脏利什曼病是由利什曼原虫（Leishmania（L.）婴儿当寄生虫破坏宿主的免疫反应时，这种疾病就建立起来了。值得注意的是，基于化学疗法的锑化合物的使用可以部分减轻疾病负担。不幸的是，在该疾病流行的地区，对药物治疗的抗药性正在增加。在这份报告中，我们研究了免疫反应的巨噬细胞感染antimony-resistantL。婴儿从疾病复发的患者中分离出来。结果表明，抗锑寄生虫持续在感染的第一个24小时。感染期间巨噬细胞的活化或硫醇产生的阻断显示寄生虫的清除增强，这与促炎细胞因子的产生增加协同相关。这些结果表明，L.婴儿分离物可能与巨噬细胞杀微生物功能的降低有关。
Visceral leishmaniasis is a severe disease caused by protozoan parasites that includeLeishmania (L.) infantum. The disease is established when parasites subvert the immune response of the host. Notably, chemotherapy-based use of antimonial compounds can partially alleviate disease burden. Unfortunately, the resistance to drug treatments is increasing in areas endemic to the disease. In this report, we investigated immune responses within macrophages infected with antimony-resistantL. infantumisolates from patients with a relapse in the disease. Results revealed that antimony-resistant parasites persist in the first 24 h of infection. Activation of macrophage or blocking of thiol production during infection shows enhanced clearance of parasites, which is coordinately associated with increased production of pro-inflammatory cytokines. Taken together, these results suggest that the mechanism of antimony resistance inL. infantumisolates may be related to a decrease in macrophage microbicidal functions.