The nitric oxide synthesis inhibitor L-NAME facilitates associative learning.
The nitric oxide synthesis inhibitor L-NAME facilitates associative learning.
复制标题
一氧化氮合成抑制剂 L-NAME 有助于联想学习。
DOI：
10.1016/s0278-5846(96)00105-4
复制
发表时间：
1996
影响因子：
5.6
通讯作者：
Harvey,JA
中科院分区：
文献类型：
--
作者：
Du,W;Harvey,JA
1. Nitric oxide has been suggested to play an important role in synaptic plasticity and in learning. 2. The authors examined the effects of NW-nitro-L-arginine methyl ester, a competitive and enantiomeric specific inhibitor of nitric oxide synthase, on classical conditioning of the rabbit's nictitating membrane response. 3. It was found that L-NAME significantly enhanced the acquisition of conditioned responses. 4. The enhanced conditioned responses were not due to a sensitization of the conditioned and unconditioned reflexes or to changes in baseline levels of responding. 5. The dose and route of administration of L-NAME employed in this study had no effect on blood pressure. 6. These results suggest that nitric oxide normally functions as a tonic inhibitory modulator of associative learning and that procedures aimed at decreasing its production may provide a novel approach for improving learning.
