DNA Methylation Signature of Aging: Potential Impact on the Pathogenesis of Parkinson's Disease.
DNA Methylation Signature of Aging: Potential Impact on the Pathogenesis of Parkinson's Disease.
复制标题
衰老的DNA甲基化特征：对帕金森氏病的发病机理的潜在影响。
DOI：
10.3233/jpd-223517
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Kang SU
中科院分区：
文献类型：
--
作者：
Yazar V;Dawson VL;Dawson TM;Kang SU
通过表观遗传修饰调节基因表达是指在不改变DNA序列的情况下，对基因功能进行持久和可遗传的改变。在迄今发现的所有表观遗传学机制中，DNA甲基化在过去十年中一直是衰老和与年龄相关的疾病研究中特别感兴趣的，因为在衰老过程中特定部位DNA甲基化变化的一致性可以预测未来的健康和寿命。越来越多的证据表明，整个生命周期中发生的DNA(去)甲基化事件的动态性质在衰老和与年龄相关的神经退行性疾病(包括帕金森病(PD))的病理生理学中发挥了作用。在这方面，PD甲基组在某种程度上显示出在匹配年龄的健康个体的甲基组中观察到的类似的全基因组变化。在这篇综述中，我们首先简要概述DNA甲基化的全球模式，然后在衰老和帕金森病的背景下，它的机制和调节。考虑到不同的神经退行性变实验和动物模型的不同证据线，以及它们如何结合在一起塑造我们目前对健康和疾病中DNA甲基组的组织特异性变化的理解，我们报告了大脑基因组甲基化状况的高水平比较，重点是帕金森病和自然衰老中的多巴胺能神经元。我们相信，这将特别有助于系统地解剖PD和健康衰老过程中DNA甲基化重叠的全基因组变化，并有助于提高我们对独立于衰老过程的PD特异性甲基化模式的了解。
Regulation of gene expression by epigenetic modifications means lasting and heritable changes in the function of genes without alterations in the DNA sequence. Of all epigenetic mechanisms identified thus far, DNA methylation has been of particular interest in both aging and age-related disease research over the last decade given the consistency of site-specific DNA methylation changes during aging that can predict future health and lifespan. An increasing line of evidence has implied the dynamic nature of DNA (de)methylation events that occur throughout the lifespan has a role in the pathophysiology of aging and age-associated neurodegenerative conditions, including Parkinson’s disease (PD). In this regard, PD methylome shows, to some extent, similar genome-wide changes observed in the methylome of healthy individuals of matching age. In this review, we start by providing a brief overview of studies outlining global patterns of DNA methylation, then its mechanisms and regulation, within the context of aging and PD. Considering diverging lines of evidence from different experimental and animal models of neurodegeneration and how they combine to shape our current understanding of tissue-specific changes in DNA methylome in health and disease, we report a high-level comparison of the genomic methylation landscapes of brain, with an emphasis on dopaminergic neurons in PD and in natural aging. We believe this will be particularly useful for systematically dissecting overlapping genome-wide alterations in DNA methylation during PD and healthy aging, and for improving our knowledge of PD-specific changes in methylation patterns independent of aging process.
影响因子：
3.7
作者：
Ciccarone F;Klinger FG;Catizone A;Calabrese R;Zampieri M;Bacalini MG;De Felici M;Caiafa P
通讯作者：
Caiafa P
DOI：
10.1016/j.mcn.2017.11.002
发表时间：
2018-01
期刊：
Molecular and cellular neurosciences
影响因子：
--
作者：
Lardenoije R;van den Hove DLA;Havermans M;van Casteren A;Le KX;Palmour R;Lemere CA;Rutten BPF
通讯作者：
Rutten BPF