Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells
Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells
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DOI：
10.4028/www.scientific.net/msf.706-709.520
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发表时间：
2012-01
期刊：
影响因子：
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通讯作者：
A. Kagawa;K. Katsura;M. Mizumoto;Yutaka Tagawa;Yoichi Masiko
中科院分区：
文献类型：
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作者：
A. Kagawa;K. Katsura;M. Mizumoto;Yutaka Tagawa;Yoichi Masiko
研究了Pd-Ni基贮氢合金（HSAs）放氢对培养细胞的影响。电池对放电氢的敏感性因电池种类而异。在正常细胞中没有观察到影响，而在HAS附近观察到杀死癌细胞的效果，并且观察到细胞死亡的区域限于距离合金表面几mm的范围。为了探讨其原因，从合金表面释放的气态氢和氢自由基的量和生理盐水溶液的pH值的变化。溶液进行了测量。气态氢和氢自由基的量随时间增加。生理盐水溶液的pH值。溶液先下降，约50小时后恢复至起始值。pH变化行为随合金成分而变化。推测合金表面形成的氢自由基可能引起癌细胞的特征性变化，从而导致放电氢对癌细胞的死亡作用。
The influence of discharged hydrogen from Pd-Ni based hydrogen storage alloys (HSAs) on cultured cells has been investigated. The susceptibility of cells to discharged hydrogen varied with the kind of cells. No influence was seen in the normal cells, while an effect of killing cancer cells was observed near the HAS and the region where the cell death was observed was limited to an extent of a few mm from the alloy surface. In order to examine the cause of the effects, the amount of gaseous hydrogen and hydrogen radicals released from the alloy surface and pH change of physiological saline aq. solution were measured. The amount of gaseous hydrogen and hydrogen radicals increased with time. The pH of physiological saline aq. solution decreased first and then recovered to the starting value after about 50h. The pH change behavior varied with alloy composition. It is inferred that the hydrogen radicals formed on alloy surface may bring a characteristic change in the cancer cells, leading to the effect of discharged hydrogen on cancer cell death.