Sevoflurane anesthesia induces neither contextual fear memory impairment nor alterations in local population connectivity of medial prefrontal cortex local field potentials networks in aged rats
Sevoflurane anesthesia induces neither contextual fear memory impairment nor alterations in local population connectivity of medial prefrontal cortex local field potentials networks in aged rats
复制标题
七氟烷麻醉既不会引起老年大鼠情境恐惧记忆损伤，也不会引起内侧前额叶皮层局部场电位网络的局部群体连接性改变
DOI：
10.1111/fcp.12194
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发表时间：
2016
影响因子：
2.9
通讯作者：
Wang Guolin
中科院分区：
文献类型：
--
作者：
Xu Xinyu;Zhang Qian;Tian Xin;Wang Guolin
七氟醚被发现增加了与阿尔茨海默病相关的细胞凋亡和病理标志物，引起了人们对它们对术后认知功能障碍的潜在贡献的担忧。本研究旨在探讨七氟醚对老年大鼠情景恐惧记忆的影响，以及在情景恐惧记忆过程中老年大鼠内侧前额叶皮质(MPFC)局部场电位(LFP)的局部群体连接性。将18个月龄雄性SD大鼠在mPFC内植入一个多道电极阵列。将老年大鼠分为对照组、七氟醚组(七氟醚1MAC，持续2 h)和手术组(七氟醚1.0 MAC，麻醉2 h)，观察麻醉对大鼠情景恐惧记忆的影响，并用部分定向连贯性(PDC)检测mPFC LFP网络局部群体连接的变化。在手术和麻醉后第1天，手术损害了老年大鼠mPFC LFP网络的上下文恐惧记忆和局部群体连通性。1MAC七氟醚麻醉在暴露后1，7，15，30d均未引起老年大鼠mPFC LFP网络上下文恐惧记忆障碍和局部群体连通性改变(P>；0.05)。在麻醉后1、7、15和30天的情境恐惧记忆过程中，Theta带mPFC LFP的PDC值显著增加。我们的结果提示：1MAC七氟醚麻醉不会导致老年大鼠情境恐惧记忆障碍，提示mPFC theta条带LFP局部群体连接性增强在情境恐惧记忆中起一定作用。
Sevoflurane has been found to increase apoptosis and pathologic markers associated with Alzheimer disease, provoking concern over their potential contribution to postoperative cognitive dysfunction. This study aimed to determine the effects of sevoflurane on contextual fear memory of aged rats and to characterize local population connectivity of local field potentials (LFPs) in medial prefrontal cortex (mPFC) of aged rats during contextual fear memory. Eighteen‐month‐old male SD rats were implanted with one multichannel electrode array in mPFC. The aged rats were divided into control group, sevoflurane group (1 MAC sevoflurane for 2 h) and surgical group with 1.0 MAC sevoflurane for 2 h. We then assessed the effect of the anesthesia on contextual fear memory, and alterations in the local population connectivity of mPFC LFP networks by partial directed coherence (PDC). Surgery impaired contextual fear memory and reduced local population connectivity of mPFC LFP networks in aged rats at day 1 after the surgery and anesthesia. 1 MAC Sevoflurane anesthesia induced neither contextual fear memory impairment nor alterations in local population connectivity of mPFC LFP networks in aged rats when tested 1, 7, 15 and 30 days after exposure (P > 0.05). PDC values of theta band mPFC LFPs became strongly increased during contextual fear memory at 1, 7, 15, and 30 days after anesthesia. Our results suggest that 1 MAC sevoflurane anesthesia does not induce contextual fear memory impairment in aged rats and suggest that the increased local population connectivity in theta bands LFPs of mPFC plays a role in contextual fear memory.