The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping.
The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping.
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DOI：
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发表时间：
1999-03
期刊：
影响因子：
4.6
通讯作者：
M. Campione;H. Steinbeisser;A. Schweickert;K. Deissler;F. Bebber;L. Lowe;Sonja Nowotschin;C. Viebahn;Pascal Haffter;M. Kuehn;M. Blum
中科院分区：
文献类型：
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作者：
M. Campione;H. Steinbeisser;A. Schweickert;K. Deissler;F. Bebber;L. Lowe;Sonja Nowotschin;C. Viebahn;Pascal Haffter;M. Kuehn;M. Blum
脊椎动物的左右不对称是由左侧板发出的活动控制的。这些信号如何传递到形成器官尚不清楚。小鼠、青蛙和斑马鱼胚胎中的候选介质是同源框基因Pitx2。在左外板中胚层、管状心脏和早期肠管中不对称表达。当这些器官发生不对称环状形态发生时，局部Pitx2表达继续。Xnr1在非洲爪蟾右侧板的异位表达诱导Pitx2转录。Pitx2的错误表达影响器官的位置和形态。这些实验表明Pitx2在促进线性心脏和肠道循环中的作用。
Left-right asymmetry in vertebrates is controlled by activities emanating from the left lateral plate. How these signals get transmitted to the forming organs is not known. A candidate mediator in mouse, frog and zebrafish embryos is the homeobox gene Pitx2. It is asymmetrically expressed in the left lateral plate mesoderm, tubular heart and early gut tube. Localized Pitx2 expression continues when these organs undergo asymmetric looping morphogenesis. Ectopic expression of Xnr1 in the right lateral plate induces Pitx2 transcription in Xenopus. Misexpression of Pitx2 affects situs and morphology of organs. These experiments suggest a role for Pitx2 in promoting looping of the linear heart and gut.