Polymorphisms of DNA repair gene XRCC1 and hepatocellular carcinoma risk among East Asians: a meta-analysis
Polymorphisms of DNA repair gene XRCC1 and hepatocellular carcinoma risk among East Asians: a meta-analysis
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DOI：
10.1007/s13277-012-0546-5
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发表时间：
2013-02-01
期刊：
影响因子：
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通讯作者：
Zhang, Shuijun
中科院分区：
文献类型：
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作者：
Li, Jie;Li, Zhenzhen;Zhang, Shuijun
肝细胞癌（HCC）中X射线修复交叉互补组1（XRCC 1）多态性（Arg 194 Trp，Arg 280 His和Arg 399 Gln）的相关研究显示了相互矛盾的结果。本研究的目的是定量总结这种关系的证据。检索PubMed、Embase、CNKI和中国生物医学数据库中的已发表文献。采用固定或随机效应模型计算合并比值比（OR）和95%置信区间（CI）。包括3，011例HCC病例和3，619例对照的13项研究被纳入XRCC 1 Arg 399 Gln多态性与HCC风险之间关联的荟萃分析。结果表明，Arg 399 Gln基因多态性与肝癌的危险性呈共显性模型（Gln/Gln vs. Arg/Arg，OR = 1.32，95% CI = 1.08-1.61; Arg/Gln vs. Arg/Arg，OR = 1.41，95% CI = 1.12-1.80）和显性模型（Gln/Gln + Arg/Gln vs. Arg/Arg，OR = 1.39，95%CI = 1.15-1.69），但不属于隐性模型（Gln/Gln vs. Arg/Gln + Arg/Arg，OR = 1.13，95%CI = 0.95-1.35）。将分析限制在Hardy-Weinberg平衡内的研究，结果具有持久性和稳健性。当按地区和对照来源分层时，在任何亚组中均观察到持续性结果。没有发现Arg 194 Trp（980例HCC病例和966例对照）和Arg 280 His（1，200例HCC病例和1，236例对照）与HCC风险相关的证据。本荟萃分析的结果表明，XRCC 1的Arg 399 Gln多态性可能是东亚人群肝癌的遗传易感性。此外，还需要大量精心设计的研究来证实这一结论。
Association studies on the X-ray repair cross-complementing group 1 (XRCC1) polymorphisms (Arg194Trp, Arg280His, and Arg399Gln) in hepatocellular carcinoma (HCC) have shown conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Published literatures from PubMed, Embase, CNKI, and Chinese Biomedicine Database were retrieved. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed- or random-effects model. Thirteen studies including 3,011 HCC cases and 3,619 controls were included in the meta-analysis of the association between XRCC1 Arg399Gln polymorphism and HCC risk. The results indicated that Arg399Gln polymorphism was significantly associated with risk of HCC in a codominant model (Gln/Gln vs. Arg/Arg, OR = 1.32, 95 % CI = 1.08-1.61; Arg/Gln vs. Arg/Arg, OR = 1.41, 95 % CI = 1.12-1.80) and a dominant model (Gln/Gln + Arg/Gln vs. Arg/Arg, OR = 1.39, 95 % CI = 1.15-1.69), but not in a recessive model (Gln/Gln vs. Arg/Gln + Arg/Arg, OR = 1.13, 95 % CI = 0.95-1.35). Limiting the analysis to the studies within Hardy-Weinberg equilibrium, the results were persistent and robust. When stratifying for region and source of controls, persistent results were observed in any subgroup. No evidence of association of Arg194Trp (980 HCC cases and 966 controls) and Arg280His (1,200 HCC cases and 1,236 controls) with HCC risk was found. No publication bias was found in the present study. The results from the present meta-analysis indicated that the Arg399Gln polymorphisms of XRCC1 may be a genetic susceptibility for HCC in the East Asian population. Further, large and well-designed studies are needed to confirm this conclusion.