HIV disease progression: Depression, stress, and possible mechanisms
HIV disease progression: Depression, stress, and possible mechanisms
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DOI：
10.1016/s0006-3223(03)00323-8
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发表时间：
2003-08-01
影响因子：
10.6
通讯作者：
Leserman, J
中科院分区：
文献类型：
--
作者：
Leserman, J
人们对抑郁和压力是否可以解释感染人类免疫缺陷病毒（HIV）的患者病程的广泛变异性很感兴趣。本文总结了大量的证据，检查抑郁和压力是否可能对HIV疾病的免疫和疾病相关参数产生影响。此外，我们回顾了已知的HIV疾病的潜在生物学机制，如糖皮质激素和儿茶酚胺的改变，这可能有助于解释这些心理免疫关系。我们的文献回顾发现大量证据表明，慢性抑郁症和压力事件可能会影响艾滋病毒疾病的进展。然而，我们对可能解释这些关系的生物学机制知之甚少。有必要进行更多的研究，以调查抑郁和压力如何影响艾滋病毒疾病的进展，以及什么类型的干预措施可以减轻慢性抑郁和创伤的负面影响。(C)2003生物精神病学学会。
There is much interest in whether depression and stress may explain the wide variability in the disease course of patients infected with human immunodeficiency virus (HIV). This article summarizes the large body of evidence examining whether depression and stress may have an impact on immune- and disease-related parameters in HIV disease. Furthermore, we review what is known about the underlying biological mechanisms of HIV disease, such as alterations in glucocorticoids and catecholamines, which may help explain these psychoimmune relationships. Our review of the literature finds substantial evidence that chronic depression and stressful events may affect HIV disease progression. We know little, however, regarding the biological mechanisms that may account for these relationships. More research is warranted to investigate how depression and stress might impact HIV disease progression and what types of interventions might mitigate the negative impact of chronic depression and trauma. (C) 2003 Society of Biological Psychiatry.