Pain thresholds during and after treatment of severe depression with electroconvulsive therapy
Pain thresholds during and after treatment of severe depression with electroconvulsive therapy
复制标题
DOI：
10.1016/j.ejpain.2003.11.015
复制
发表时间：
2004-10-01
影响因子：
3.6
通讯作者：
Jensen, TS
中科院分区：
文献类型：
--
作者：
Gormsen, L;Ribe, AR;Jensen, TS
疼痛和抑郁通常相关，这表明这两种情况具有共同的神经生物学机制，调节情绪功能和有害信息的处理。据推测，抑郁症患者的疼痛阈值会发生改变，并随着抑郁症的改善而正常化。因此，本研究的目的是确定严重抑郁症患者在接受电休克疗法 (ECT) 治疗期间和之后以及健康对照组的疼痛阈值。十七名抑郁症患者（汉密尔顿抑郁评分> 18）和年龄和性别匹配的相同规模的对照组参加了该研究。在 ECT 期间和之后，对抑郁患者的疼痛检测和压力耐受阈值以及通过暴露于冰水的冷加压测试的疼痛耐受阈值进行了两次测量，并在相似的时间间隔内对对照组进行了两次测量。虽然 ECT 显着改善了汉密尔顿抑郁评分（从平均 23.9 (SD:5) 到平均 12.5 (SD:5.7)），但患者组在 ECT 期间和之后疼痛阈值没有显着变化。然而，抑郁症患者在两次检查的冷加压测试中以及在第二天检查时的压力疼痛耐受性均显着低于相应的对照受试者。 ECT 对抑郁评分和疼痛处理的不同影响表明，情绪和伤害性处理并非由同一系统直接调节，但疼痛和抑郁之间存在复杂的关系。 (C) 2003 年国际疼痛研究协会欧洲分会联合会。由爱思唯尔有限公司出版。保留所有权利。
Pain and depression are often associated suggesting that both conditions share a common neurobiological mechanism, which modulate emotional function and processing of noxious information. Pain thresholds are hypothesized to be altered in depressed patients and normalized with the amelioration of depression. The purpose of this study was therefore to determine pain thresholds in patients during and after treatment with electroconvulsive therapy (ECT) of severe depression and in healthy controls. Seventeen depressed patients (Hamilton depression score > 18) and an age and gender matched control group of same size participated in the study. Pain detection and tolerance thresholds to pressure and pain tolerance thresholds to the Cold Pressor Test by exposure to ice-water was measured twice in depressed patients during and after ECT and twice in controls with a similar time interval. While ECT significantly improved Hamilton depression score (from mean 23.9 (SD:5) to mean 12.5 (SD:5.7)) there was no significant change in pain thresholds during and after ECT in the patient group. However, depressed patients had significantly lower pain tolerance in the Cold Pressor Test on both examinations and on pressure pain tolerance on the second examination day than their corresponding control subjects. The differential effect of ECT on depression score and pain processing indicate that mood and noxious processing are not medicated directly by the same systems but that a complex relationship between pain and depression exists. (C) 2003 European Federation of Chapters of the International Association for the Study of Pain. Published by Elsevier Ltd. All rights reserved.