An open-label, double tympanocentesis study of levofloxacin therapy in children with, or at high risk for, recurrent or persistent acute otitis media
An open-label, double tympanocentesis study of levofloxacin therapy in children with, or at high risk for, recurrent or persistent acute otitis media
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DOI：
10.1097/01.inf.0000246828.13834.f9
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发表时间：
2006-12-01
影响因子：
3.6
通讯作者：
Noel, Gary J.
中科院分区：
文献类型：
--
作者：
Arguedas, Adriano;Dagan, Ron;Noel, Gary J.
背景：左氧氟沙星对常见呼吸道病原体具有良好的抗菌活性，因此可能是治疗儿童持续性中耳炎或复发性中耳炎的有效药物。目的：本研究的目的是评价左氧氟沙星对持续性或复发性中耳炎儿童中耳液中细菌的清除效果和安全性。方法：采用开放的多中心试验，在开始使用左氧氟沙星(10 mg/kg，每日2次，共10天)后3~5天进行鼓室穿刺术。结果：205名儿童(80%)在开始使用左氧氟沙星(10 mg/kg，每日2次，共10天)后进行鼓室穿刺术
Background: Levofloxacin has excellent activity against common respiratory pathogens and therefore is likely to be effective in treating children with persistent or recurrent otitis media.Objective: The objective of this study was to assess the efficacy and safety of levofloxacin treatment in the eradication of bacterial pathogens from the middle ear fluid (MEF) of children with, or at high risk for, persistent or recurrent otitis media.Methods: An open-label multicenter trial was conducted that involved tympanocentesis at entry and selectively 3 to 5 days after starting levofloxacin (10 mg/kg twice a day for 10 days).Results: Two hundred five children (80%