Signaling from the adherens junction.
Signaling from the adherens junction.
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DOI：
10.1007/978-94-007-4186-7_8
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发表时间：
2012
影响因子：
--
通讯作者：
Gottardi, Cara J
中科院分区：
文献类型：
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作者：
McEwen, Abbye E;Escobar, David E;Gottardi, Cara J
钙粘蛋白/连环蛋白复合物组织形成连接相邻细胞的细胞骨架网络的结构性Velcro。这种复合物的功能丧失会阻止正常组织的发育，多年的研究已经梳理出粘连的物理结构如何将信息传递到细胞内部。大多数钙粘蛋白结合伴侣也定位于细胞核以调节转录的证据支持了钙粘蛋白作为核信号的简单化学计量抑制剂的观点。然而，同样清楚的是，基于钙粘蛋白的粘附启动了各种分子事件，这些分子事件最终可以影响核信号传导。本章讨论了这两种模式的钙粘蛋白信号的背景下，组织的生长和分化。
The cadherin/catenin complex organizes to form a structural Velcro that joins the cytoskeletal networks of adjacent cells. Functional loss of this complex arrests the development of normal tissue organization, and years of research have gone into teasing out how the physical structure of adhesions conveys information to the cell interior. Evidence that most cadherin-binding partners also localize to the nucleus to regulate transcription supports the view that cadherins serve as simple stoichiometric inhibitors of nuclear signals. However, it is also clear that cadherin-based adhesion initiates a variety of molecular events that can ultimately impact nuclear signaling. This chapter discusses these two modes of cadherin signaling in the context of tissue growth and differentiation.