Expression of polysialylated N-CAM in the central nervous system of adult canaries and its possible relation to function.
Expression of polysialylated N-CAM in the central nervous system of adult canaries and its possible relation to function.
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多唾液酸化 N-CAM 在成年金丝雀中枢神经系统中的表达及其与功能的可能关系。
DOI：
10.1002/cne.903560411
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Nottebohm,F
中科院分区：
文献类型：
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作者：
Rousselot,P;Nottebohm,F
多唾液化神经元细胞粘附分子（PSAqN‐CAM）是一种与神经元发生构型变化或空间易位相关的细胞表面分子。在这两种情况下，这种分子被认为降低了这些细胞或其过程的粘附性，从而可以暗示它们自己进入现有的薄壁组织。我们使用PSA特异性单克隆抗体提供我们认为是PSA - N - CAM在成年鸣禽大脑中分布的第一个说明。该抗体可染色多种细胞类别和过程，如下：(1)心室区细胞子集；(2)被认为是神经母细胞的迁移细胞；(3)分化神经元的子集；(4)部分脑表面星形胶质细胞；(5)部分伸长细胞；(6)部分区域的神经膜；(7)部分轴突纤维；(8)可能还有一些突触。我们的研究结果也首次证明了远脑中大量迁移细胞的广泛分布，以及成人大脑中PSA - Nq - CAM表达的季节性调节，这些细胞的募集和功能会发生季节性变化。然而，我们没有发现PSA - N - CAM与高声带中枢（HVC）的年轻迁移细胞相关，也没有发现PSA - N - CAM存在于强健的管状核（RA）中，后者已知接收来自HVC的新的轴突末梢。在这些情况下，空间移位可能在其他表面分子的帮助下发生。©1995 Wiley‐Liss, Inc。
Polysialylated neuronal cell adhesion molecule (PSAqN‐CAM) is a cell surface molecule associated with neurons that undergo changes in configuration or spatial translocation. In both cases, this molecule is thought to reduce the adhesivity of these cells or of their processes, which can thereby insinuate themselves into the existing parenchyma. We used a monoclonal antibody specific to PSA to offer what we believe is the first account of the distribution of PSA‐N‐CAM in the adult songbird brain. This antibody stained a diversity of cell classes and processes, as follows: (1) a subset of ventricular zone cells; (2) migrating cells thought to be neuroblasts; (3) a subset of differentiated neurons; (4) some brain surface astrocytes; (5) some tanycytes; (6) the neuropil of some regions; (7) some axonal fibers; and (8) possibly some synapses. Our results demonstrate also, for the first time, the wide distribution of a very numerous population of migrating cells in the telencephalon and the seasonal regulation of PSA‐Nq‐CAM expression in a part of the adult brain known to undergo seasonal changes in cell recruitment and function. However, we did not find PSA‐N‐CAM associated with young migrating cells in the high vocal center (HVC), nor was there PSA‐N‐CAM in the robust nucleus of the archistriatum (RA), which is known to receive new axonal endings from HVC. In these instances spatial translocation may occur with the assistance of other surface molecules. © 1995 Wiley‐Liss, Inc.