Transcription elongation. Heterogeneous tracking of RNA polymerase and its biological implications.
Transcription elongation. Heterogeneous tracking of RNA polymerase and its biological implications.
复制标题
转录伸长。 RNA聚合酶的异质跟踪及其生物学意义。
DOI：
10.4161/trns.28285
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kashlev M
中科院分区：
文献类型：
--
作者：
Imashimizu M;Shimamoto N;Oshima T;Kashlev M
通过RNA聚合酶的暂停来调节转录延伸具有多种生理作用。暂停机制取决于被转录的DNA的序列异质性，以及聚合酶与特定DNA序列的某些相互作用。为了描述调节的机制，我们将异质性的概念引入到先前提出的伸长、动力冲程和布朗棘轮的替代模型中。我们还讨论了异质性的分子起源和生理意义。
Regulation of transcription elongation via pausing of RNA polymerase has multiple physiological roles. The pausing mechanism depends on the sequence heterogeneity of the DNA being transcribed, as well as on certain interactions of polymerase with specific DNA sequences. In order to describe the mechanism of regulation, we introduce the concept of heterogeneity into the previously proposed alternative models of elongation, power stroke and Brownian ratchet. We also discuss molecular origins and physiological significances of the heterogeneity.