COMPARISON OF ERROR PATTERNS PRODUCED BY SCOPOLAMINE AND MK-801 ON REPEATED ACQUISITION AND TRANSITION BASE-LINES
COMPARISON OF ERROR PATTERNS PRODUCED BY SCOPOLAMINE AND MK-801 ON REPEATED ACQUISITION AND TRANSITION BASE-LINES
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DOI：
10.1007/bf02245144
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发表时间：
1992-06-01
影响因子：
3.4
通讯作者：
CORYSLECHTA, DA
中科院分区：
文献类型：
--
作者：
COHN, J;ZIRIAX, JM;CORYSLECHTA, DA
胆碱能和多巴胺能系统的差异作用的理解可能是有限的，未能移动学习障碍的分析超出了整体准确性的变化的评估。本文报道了两项研究的结果，其中比较了东莨菪碱（0.5-3.0 mg/kg IP）（一种胆碱能拮抗剂）和MK-801（0.05-0.3 mg/kg IP）（一种NMDA受体拮抗剂）在两种不同的重复学习程序中对大鼠的影响，并评价了每种程序产生的潜在错误模式的性质。第一项研究检查了药物对重复序列采集程序的影响，发现虽然两种药物均以剂量依赖性方式降低总体准确性，但主要错误模式随药物而显著变化;东莨菪碱主要在序列内产生跳跃错误，而MK-801更显著地增加了序列第一和第二成员的持续性。在第二项研究中，使用了重复的过渡程序，两种药物再次以剂量依赖性方式显著降低了整体准确性，但没有观察到药物产生的错误模式的一致差异。因此，虽然胆碱能和NMDA系统在学习中发挥作用，但导致整体准确性变化的行为过程可能不同，如东莨菪碱和MK-801在重复采集基线中产生的错误的差异模式所示。此外，东莨菪碱和MK-801的基础行为过程中观察到的差异，在重复收购，但不是在重复的过渡过程表明，这两种药物中的每一种可能会影响一个以上的变量控制行为，与药物相关的变化，控制变量的相对影响取决于操作的学习任务的偶然性。
An understanding of the differential role of cholinergic and glutaminergic systems may be limited by the failure to move the analysis of learning impairments beyond an assessment of changes in overall accuracy. This paper reports the results of two studies in which the effects in rats of scopolamine (0.5-3.0 mg/kg IP), a cholinergic antagonist, and MK-801 (0.05-0.3 mg/kg IP), an NMDA-receptor antagonist, were compared in two different repeated learning procedures and the nature of the underlying error patterns produced by each was evaluated. The first study examined drug effects upon a repeated sequence acquisition procedure and found that while both drugs decreased overall accuracy in a dose-dependent manner, the predominant error pattern varied significantly with drug; scopolamine primarily produced skipping errors within the sequence, whereas MK-801 more prominently increased perseveration on the first and second members of the sequence. In the second study, which used a repeated transition procedure, both drugs again significantly decreased overall accuracy in a dose-dependent manner, but no consistent differences in error patterning produced by the drugs were observed. Thus, while both cholinergic and NMDA systems play a role in learning, the behavioral processes underlying the changes in overall accuracy may differ, as indicated by the differential patterns of errors produced by scopolamine and MK-801 in the repeated acquisition baseline. Furthermore, the observed differences in the underlying behavioral processes of scopolamine and MK-801 in the repeated acquisition but not on the repeated transition procedure suggest that each of the two drugs may affect more than one of the variables controlling behavior, with the relative impact of drug-related changes in controlling variables depending upon the operative contingencies of the learning task.