The Secretion of α-Ecdysone by the Prothoracic Glands of Manduca sexta In Vitro

The Secretion of α-Ecdysone by the Prothoracic Glands of Manduca sexta In Vitro
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离体天蛾前胸腺分泌α-蜕皮激素

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发表时间：
1974
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影响因子：
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通讯作者：
L. Gilbert
L. Gilbert
中科院分区：
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文献类型：
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作者：
D. S. King;W. Bollenbacher;D. Borst;W. Vedeckis;J. D. O'connor;P. I. Ittycheriah;L. Gilbert

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摘要
Abstract Prothoracic glands of tobacco hornworm larvae cultured in vitro secrete into the culture medium a substance which was active in ecdysone bioassays and determined to be ecdysone-like by radioimmunoassay. The prothoracic glands appear to be the sole source of this substance. The material was identified as α-ecdysone by thin-layer, gas-liquid, and high-resolution liquid chromatography and mass spectrometry. No other active moulting principles were present in the medium. It appears that the prothoracic gland secretes a prohormone, α-ecdysone, which is subsequently converted into the active moulting hormone, β-ecdysone, in other insect tissues.