Organocatalytic asymmetric ring-opening of aziridines
Organocatalytic asymmetric ring-opening of aziridines
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DOI：
10.1039/b812369a
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发表时间：
2008-10-07
影响因子：
3.2
通讯作者：
Jorgensen, Karl Anker
中科院分区：
文献类型：
--
作者：
Paixao, Mircio W.;Nielsen, Martin;Jorgensen, Karl Anker
在手性PTC条件下，通过β-酮酯对N-甲苯磺酰基保护的氮杂环丙烷进行有机催化开环，从而形成光学活性的氨基乙基官能化化合物，其ee高达99%。
The organocatalytic ring-opening of N-tosyl protected aziridines by beta-ketoesters under chiral PTC-conditions, leading to the formation of optically active aminoethyl functionalised compounds with up to 99% ee, has been developed.