Effects of atrial natriuretic peptide on acute renal impairment in patients with heart failure after cardiac surgery
Effects of atrial natriuretic peptide on acute renal impairment in patients with heart failure after cardiac surgery
复制标题
心房钠尿肽对心脏术后心力衰竭患者急性肾功能损害的影响
DOI：
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发表时间：
1994
影响因子：
38.9
通讯作者：
Stefan Lundin
中科院分区：
文献类型：
--
作者：
F. Valsson;S.;Thomas Hedner;Stefan Lundin
ObjectiveTo investigate the effects of IV infusion of atrial natriuretic peptide (human ANP 1–28) on renal function in patients with acute heart failure and renal impairment after cardiac surgery.DesignPharmocodynamic, dose-effect investigation.SettingCardiothoracic Intensive Care Unit of a university hospital.PatientsTwelve patients (mean age 68 years, range 44–78 years) treated with inotropic drugs and an intra-aortic balloon pump (n=8) were studied 1–3 days after cardiac surgery. Patients had acute renal impairment, defined as a rise in serum creatinine of more than 50% compared to preoperative values. Patients were receiving dopamine and furosemide infusion to increase urine flow.InterventionsBaseline measurements of glomerular filtration rate (GFR) and renal blood flow (51Cr-EDTA and PAH clearance) were first performed during two 30-min periods. ANP was then administered for two consecutive 30-min periods (25 and 50 ng/kg per min), followed by two control periods.Measurements and main resultsMean arterial pressure decreased by 6% at the highest ANP dose. Urine flow, GFR and RBF increased 62%, 43% and 38%, respectively, while renal vascular resistance decreased 30%. At this dose level, circulating ANP concentrations were on the average eight fold higher than preinfusion levels.ConclusionsANP improved renal function and decreased elevated renal vascular resistance in patients with renal dysfunction after cardiac surgery. The improvement in renal blood flow and glomerular filtration rate may be of potential therapeutic value to prevent or treat exaggerated renal vasoconstriction in patients with acute renal impairment following cardiac surgery.
