Prevalence of Human Papillomavirus in Anal and Oral Sites Among Patients with Genital Warts
Prevalence of Human Papillomavirus in Anal and Oral Sites Among Patients with Genital Warts
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DOI：
10.2340/00015555-1718
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发表时间：
2014-01-01
影响因子：
3.6
通讯作者：
Madsen, Klaus
中科院分区：
文献类型：
--
作者：
Kofoed, Kristian;Sand, Carsten;Madsen, Klaus
生殖器疣是由人乳头瘤病毒（HPV）引起的。HPV是肛门生殖器恶性肿瘤的主要原因，并且已经证明HPV在口咽癌的病因学中的作用。生殖器疣患者口腔HPV感染的频率以及伴随生殖器、肛门和口腔感染之间的关系尚不清楚。共招募了201名患有生殖器疣样病变的男性和女性。从生殖器疣和肛管获得拭子样本，并收集口腔冲洗液。46.2%的参与者发现肛门HPV，10.4%的参与者发现口腔HPV。肛门和生殖器疣HPV类型之间的一致性为78.1%，而口腔和生殖器疣类型之间的一致性为60.9%。肛门和口腔HPV类型之间的一致性较低，为21.7%。女性比男性有更多的HPV类型和肛门HPV。结论：生殖器外HPV在生殖器疣患者中很常见。似乎存在性别不平等。
Genital warts are caused by human papillomavirus (HPV). HPV is a leading cause of anogenital malignancies and a role of HPV in the aetiology of oro-pharyngeal cancers has been demonstrated. The frequency of oral HPV infection in patients with genital warts and the association between concomitant genital, anal and oral infection is unclear. A total of 201 men and women with genital wart-like lesions were recruited. Swab samples were obtained from the genital warts and the anal canal and an oral rinse was collected. Anal HPV was found in 46.2% and oral HPV in 10.4% of the participants. Concordance between anal and genital wart HPV types was 78.1%, while concordance between oral and genital wart types was 60.9%. A lower concordance of 21.7% was observed between anal and oral HPV types. Significantly more women than men had multiple HPV types and anal HPV. In conclusion, extra genital HPV is common in patients with genital warts. A gender inequality seems to exist.