Sensitivity to outcome devaluation in operant tasks is better predicted by food restriction level than reinforcement training schedule in mice.
Sensitivity to outcome devaluation in operant tasks is better predicted by food restriction level than reinforcement training schedule in mice.
复制标题
与小鼠的强化训练计划相比，通过食物限制水平可以更好地预测操作任务中对结果贬值的敏感性。
DOI：
10.1101/2023.02.23.529699
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Calipari,ErinS
中科院分区：
文献类型：
--
作者：
Chevée,Maxime;Kim,CourtneyJ;Crow,Nevin;Follman,EmmaG;Calipari,ErinS
行为策略通常根据强化是否受控制者的价值来分类。价值敏感的行为，即动物更新其行动时，改变标记值，被归类为目标导向的;相反，价值不敏感的行为，即行为保持一致时，标记值被删除或贬值，被认为是习惯性的。理解操作训练的特点，使行为控制偏向于任何一种策略，对于理解它们所依赖的认知和神经过程至关重要。使用基本的强化原则，行为可以偏向于依赖于任何一个过程：随机比率（RR）时间表被认为是促进目标导向行为的形成，而随机间隔（RI）促进习惯性控制。然而，这些任务结构的时间表特定功能与外部因素影响行为的方式还不清楚。使用不同食物限制水平的雄性和雌性小鼠，我们对每组进行RR时间表训练，其中响应-每-增强率与RI对应物相匹配，以控制增强率的差异。我们确定，食物限制水平有一个更强的影响，小鼠的行为后RR时间表比小鼠RI时间表和食物限制更好地预测敏感性的结果贬值比训练时间表。我们的研究结果支持的想法，RR或RI时间表与目标导向或习惯性行为之间的关系，分别比以前认识到的更微妙，并建议动物的参与任务必须考虑到，与结构的强化时间表，以适当地解释行为的认知基础。
Behavioral strategies are often classified based on whether reinforcement is controlled by the value of the reinforcer. Value-sensitive behaviors, in which animals update their actions when reinforcer value is changed, are classified as goal-directed; conversely, value-insensitive actions, where behavior remains consistent when the reinforcer is removed or devalued, are considered habitual. Understanding the features of operant training that bias behavioral control toward either strategy is essential to understanding the cognitive and neuronal processes on which they rely. Using basic reinforcement principles, behavior can be biased toward relying on either process: random ratio (RR) schedules are thought to promote the formation of goal-directed behaviors while random intervals (RI) promote habitual control. However, how the schedule-specific features of these task structures relate to external factors to influence behavior is not well understood. Using male and female mice on distinct food restriction levels, we trained each group on RR schedules with responses-per-reinforcer rates matched to their RI counterparts to control for differences in reinforcement rate. We determined that food restriction level has a stronger effect on the behavior of mice following RR schedules than mice following RI schedules and that food restriction better predicted sensitivity to outcome devaluation than training schedule. Our results support the idea the relationships between RR or RI schedules with goal-directed or habitual behaviors, respectively, are more nuanced than previously appreciated and suggest that an animal’s engagement in a task must be accounted for, together with the structure of reinforcement schedules, to appropriately interpret the cognitive underpinnings of behavior.