The Jejunal Absorption of Glucose Oligomers in the Absence of Pancreatic Enzymes
The Jejunal Absorption of Glucose Oligomers in the Absence of Pancreatic Enzymes
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在没有胰酶的情况下葡萄糖低聚物的空肠吸收
DOI：
10.1203/00006450-198103000-00010
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发表时间：
1981
影响因子：
3.6
通讯作者：
A. Ailabouni
中科院分区：
文献类型：
--
作者：
B. Kerzner;Howard R Sloan;G. Haase;H. J. Mcclung;A. Ailabouni
摘要：我们比较了空肠中葡萄糖低聚物溶液和葡萄糖对碳水化合物的吸收，这是一种没有胰腺分泌物的制剂。研究是在两种浓度（90和360毫克/分升）的葡萄糖和葡萄糖低聚物下进行的。葡萄糖溶液对碳水化合物的吸收（33.1 × 2.8、115.9 × 8.9 μg/cm/min）显著高于低聚物溶液（26.6 × 2.1、92.4 × 9.0 μg/cm/min） （P < 0.025、P < 0.005）。灌注液的薄层分析表明，溶出的低聚物链长可达11，表明溶出的低聚物链长甚至更大。空肠黏膜在研究过程中出现萎缩，绒毛高度与隐窝深度之比从3.8下降到0.3，麦芽糖酶、蔗糖酶和乳糖酶活性下降80%。葡萄糖低聚物（79.3 × 19.4 μg/cm/min）和葡萄糖低聚物（P < 0.005）的吸收量均显著下降（P < 0.01），但两种碳水化合物的吸收量下降相似；葡萄糖为69.8 × 14 μg/cm/min （P < 0.20）。两种碳水化合物均能提高吸水率，但葡萄糖溶液和葡萄糖低聚物溶液之间没有明显差异。溶液渗透压对水分吸收有显著影响（P < 0.025），对碳水化合物吸收无显著影响。推测：对于胰腺功能不全的患者，低渗透压的葡萄糖低聚物溶液可以提供足够的热量来源。虽然葡萄糖比空肠短段的葡萄糖低聚物更容易被吸收，但小肠的长度应该足以弥补这种差异。葡萄糖低聚物的~h~吸收可能是聚合物长度的函数，因此根据链长分离亚组分的研究将证明哪些低聚物被最有效地吸收。这些信息可能为构建胰功能不全患者理想的碳水化合物补充剂提供理论依据。
Summary: We compared the absorption of carbohydrate from solutions of glucose oligomers and glucose in jejunal Thiry-Vella fistulae, a preparation deprived of pancreatic secretions. The studies were performed with two concentrations (90 and 360 mg/dl) of both glucose and the glucose oligomers. Carbohydrate absorption from glucose solutions (33.1 × 2.8, 115.9 × 8.9 μg/cm/min) was significantly greater (P < 0.025; P < 0.005) than that from oligomer solutions (26.6 × 2.1 and 92.4 × 9.0 μg/cm/min). Thin-layer analyses of the perfusates demonstrate digestion of oligomers with a chain length up to eleven and suggest digestion of oligomers of even greater chain length. Atrophy of the jejunal mucosa occurred over the course of the study as evidenced by a decrease in the ratio of villous height to crypt depth from 3.8 to 0.3, and by a 80% decrease in the activity of maltase, sucrase, and lactase. Atrophy was accompanied by a significant decline in the absorption of both glucose oligomers (P < 0.005) and glucose (P < 0.01) from the more concentrated solutions but the decrement in absorption of both carbohydrates was similar, glucose oligomers, 79.3 × 19.4 μg/cm/min; and glucose, 69.8 × 14 μg/cm/min (P > 0.20). Water absorption was enhanced by both carbohydrates, but there was no demonstrable difference between solutions of glucose and glucose oligomers. The osmolality of the solutions clearly influenced water absorption (P < 0.025) but failed to effect the absorption of carbohydrates.Speculation: In patients with pancreatic insufficiency, solutions of glucose oligomers with low osmolality may provide an adequate source of calories. Although glucose is better absorbed than glucose oligomers from a short segment of jejunum, the length of the small intestine should be adequate to compensate for this difference.~h~ absorption of the glucose oligomers may be a function of polymer length and therefore studies with subfractions separated according to chain length will demonstrate which oligomers are most efficiently absorbed. such information may provide the theoretical hasis for the construction of an ideal carbohydrate supplement for patients with pancreatic insufficiency.