Does AMP-activated protein kinase negatively mediate aged fast-twitch skeletal muscle mass?
Does AMP-activated protein kinase negatively mediate aged fast-twitch skeletal muscle mass?
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DOI：
10.1097/jes.0b013e3181877e13
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发表时间：
2008-10
影响因子：
5.7
通讯作者：
Thomson DM
中科院分区：
文献类型：
--
作者：
Gordon SE;Lake JA;Westerkamp CM;Thomson DM
5 '-腺苷一磷酸活化蛋白激酶是细胞大小的负调节因子，其活性在静息和超负荷的快缩骨骼肌中随年龄而上调，但在慢缩骨骼肌中不上调。在这里，我们提供的证据来支持这一假设，即升高的5 '-腺苷一磷酸激活蛋白激酶活性在与年龄相关的萎缩和快速收缩骨骼肌特异性生长能力下降中起着潜在的重要综合作用。
The activity of 5'-adenosine monophosphate–activated protein kinase, a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slow-twitch muscle. Here, we provide evidence to support the hypothesis that elevated 5'-adenosine monophosphate–activated protein kinase activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle.