Characterization of two members (CST4 and CST5) of the cystatin gene family and molecular evolution of cystatin genes.
Characterization of two members (CST4 and CST5) of the cystatin gene family and molecular evolution of cystatin genes.
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半胱氨酸蛋白酶抑制剂基因家族两个成员（CST4 和 CST5）的表征以及半胱氨酸蛋白酶抑制剂基因的分子进化。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
K. Ohnishi
中科院分区：
文献类型：
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作者：
E. Saitoh;S. Isemura;K. Sanada;K. Ohnishi
半胱氨酸氨基转移酶基因家族的两个成员(CST4和CST5)已经通过DNA分析得到了部分特征。该克隆含有编码胱抑素前体形式(14 1个氨基酸)的基因S，其外显子-内含子组织结构与其他成员相同(Cst 1基因座为cystatin SN基因，Cst 2基因座为cystatin SA基因，Cst 3基因座为cystatin C基因，Cst1基因座为cystatin假基因)。在克隆CST5中发现了第二个cystatin假基因，并将其归属于CSTP2基因座。Cystatin基因与其他基因的DNA序列比对表明，Cystatin、激肽原和Bowman-Birk型抑制剂的基因是从一个古老的核糖核酸酶类基因进化而来的。
Two members (CST4 and CST5) of the cystatin gene family have been characterized partially by DNA analysis. The CST4 clone contained the gene coding for the precursor form(141 amino acids) of cystatin S, and its exon-intron organization is the same as that of other members (the cystatin SN gene at the CST1 locus, the cystatin SA gene at the CST2 locus, the cystatin C gene at the CST3 locus and a cystatin pseudogene at the CSTP1 locus). The second cystatin pseudogene was elucidated in the clone, CST5, and it was assigned to the CSTP2 locus. Alignment of DNA sequences of cystatin genes with other genes suggested that the genes for cystatins, kininogens, and Bowman-Birk type inhibitors have evolved from an ancient ribonuclease-like gene.
人半胱氨酸蛋白酶抑制剂：半胱氨酸蛋白酶抑制剂基因家族三个成员的核苷酸序列分析。
影响因子：
3.5
作者：
Saitoh,E;Kim,HS;Smithies,O;Maeda,N
通讯作者：
Maeda,N