The protocadherin-α family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse
The protocadherin-α family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse
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DOI：
10.1016/j.mcn.2008.01.016
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发表时间：
2008-05-01
影响因子：
3.5
通讯作者：
Yagi, Takeshi
中科院分区：
文献类型：
--
作者：
Hasegawa, Sonoko;Hamada, Shun;Yagi, Takeshi
表达相同气味受体的嗅觉感觉神经元 (OSN) 将其轴突投射到主嗅球中的特定肾小球。原钙粘蛋白-α (Pedba) 蛋白是多种钙粘蛋白相关分子，被编码为基因簇，高度集中在 OSN 轴突和嗅觉肾小球中。在这里，我们描述了 Pcdha 突变小鼠，其中 Pcdha 基因簇的恒定区已通过基因靶向删除。突变小鼠表现出 OSN 轴突在肾小球中的异常分类。气味受体 M71 和 MOR23 有多个小的、无关的肾小球。 M71 和 MOR23 肾小球的这些异常模式持续到成年。许多 M71 肾小球（但显然不是 MOR23 肾小球）的轴突神经支配是异质的。因此，Pcdha 分子参与 OSN 轴突与嗅球 OR 特异性肾小球的融合。 (C) 2008 Elsevier Inc. 保留所有权利。
Olfactory sensory neurons (OSNs) that express the same odorant receptor project their axons to specific glomeruli in the main olfactory bulb. Protocadherin-alpha (Pedba) proteins, diverse cadherin-related molecules that are encoded as a gene cluster, are highly concentrated in OSN axons and olfactory glomeruli. Here, we describe Pcdha mutant mice, in which the constant region of the Pcdha gene cluster has been deleted by gene targeting. The mutant mice show abnormal sorting of OSN axons into glomeruli. There are multiple, small, extraneous glomeruli for the odorant receptors M71 and MOR23. These abnormal patterns of M71 and MOR23 glomeruli persist until adulthood. Many M71 glomeruli, but apparently not MOR23 glomeruli, are heterogeneous in axonal innervation. Thus, Pcdha molecules are involved in coalescence of OSN axons into OR-specific glomeruli of the olfactory bulb. (C) 2008 Elsevier Inc. All rights reserved.