Response to antiseizure medications in neonates with acute symptomatic seizures
Response to antiseizure medications in neonates with acute symptomatic seizures
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DOI：
10.1111/epi.14671
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发表时间：
2019-03-01
期刊：
影响因子：
5.6
通讯作者：
Shellhaas, Renee A.
中科院分区：
文献类型：
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作者：
Glass, Hannah C.;Soul, Janet S.;Shellhaas, Renee A.
在一项由 534 名患有急性症状性癫痫发作的新生儿组成的前瞻性队列中，66% 的新生儿对抗癫痫药物 (ASM) 的初始负荷剂量反应不完全。治疗反应不因胎龄、性别、药物或剂量而异。颅内出血引起的癫痫发作的不完全反应风险最高，缺氧缺血性脑病的风险最低，尽管在调整高癫痫发作负荷和低温治疗后，差异并不显着。未来的试验设计可能会在患有所有急性症状性癫痫病因的新生儿中测试 ASM，并可能针对初始 ASM 难治性癫痫发作的新生儿。
In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (ASM). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic-ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Future trial design may test ASMs in neonates with all acute symptomatic seizure etiologies and could target neonates with seizures refractory to an initial ASM.