The Vitamin D/Vitamin D receptor (VDR) axis in muscle atrophy and sarcopenia
The Vitamin D/Vitamin D receptor (VDR) axis in muscle atrophy and sarcopenia
复制标题
肌肉萎缩和肌肉减少症中的维生素 D/维生素 D 受体 (VDR) 轴
DOI：
10.1016/j.cellsig.2022.110355
复制
发表时间：
2022-06-06
影响因子：
4.8
通讯作者：
Atherton, Philip J.
中科院分区：
文献类型：
--
作者：
Bollen, Shelby E.;Bass, Joseph J.;Atherton, Philip J.
肌肉萎缩和骨骼减少(这个术语指的是与年龄相关的肌肉质量和功能下降)，会影响个人跌倒、虚弱、功能衰退的风险，并最终损害生活质量。据报道，维生素D缺乏(血清中25-羟基维生素D(25(OH)D-3)水平低)会削弱肌肉力量，增加患骨质疏松症的风险。低25(OH)D-3和骨质疏松症之间的联系机制尚不完全清楚，但一些证据已经强调了活性维生素D(1，25-二羟基维生素D(1，25(OH)(2)D-3))及其核维生素D受体(VDR)在骨骼肌功能中的基因组和非基因组效应的重要性。体外研究表明，维生素D/VDR轴在调节骨骼肌萎缩的生物学过程中起着关键作用，如蛋白分解、线粒体功能、细胞衰老和肥胖。本综述的目的是从机制上综述维生素D/VDR轴在肌萎缩症中的作用机制。
Muscle atrophy and sarcopenia (the term given to the age-related decline in muscle mass and function), influence an individuals risk of falls, frailty, functional decline, and, ultimately, impaired quality of life. Vitamin D deficiency (low serum levels of 25-hydroxyvitamin D (25(OH)D-3)) has been reported to impair muscle strength and increase risk of sarcopenia. The mechanisms that underpin the link between low 25(OH)D-3 and sarcopenia are yet to be fully understood but several lines of evidence have highlighted the importance of both genomic and non-genomic effects of active vitamin D (1,25-dihydroxyvitamin D (1,25(OH)(2)D-3)) and its nuclear vitamin D receptor (VDR), in skeletal muscle functioning. Studies in vitro have demonstrated a key role for the vitamin D/ VDR axis in regulating biological processes central to sarcopenic muscle atrophy, such as proteolysis, mitochondrial function, cellular senescence, and adiposity. The aim of this review is to provide a mechanistic overview of the proposed mechanisms for the vitamin D/VDR axis in sarcopenic muscle atrophy.