Inhibitory effect of caffeic acid phenethyl ester on human leukemia HL-60 cells
Inhibitory effect of caffeic acid phenethyl ester on human leukemia HL-60 cells
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DOI：
10.1016/s0304-3835(96)04425-4
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发表时间：
1996-11-29
期刊：
影响因子：
9.7
通讯作者：
Ho, CT
中科院分区：
文献类型：
--
作者：
Chen, JH;Shao, Y;Ho, CT
以咖啡酸与苯乙醇（比例为1:5）为原料，以双环己基碳二亚胺（DCC）为缩合剂，在室温下合成咖啡酸苯乙酯（CAFE）。收益率约为38%。发现CAFE能抑制人白血病HL-60细胞的生长。抑制HL-60细胞的DNA、RNA和蛋白质合成，IC50分别为1.0 μ M、5.0 μ M和1.5 μ M。
Caffeic acid phenethyl ester (CAFE) was synthesized from caffeic acid and phenethyl alcohol (ratio 1:5) at room temperature with dicyclohexyl carbodiimide (DCC) as a condensing reagent. The yield was about 38%. CAFE was found to arrest the growth of human leukemia HL-60 cells. It also inhibits DNA, RNA and protein synthesis in HL-60 cells with IC50 of 1.0 mu M, 5.0 mu M and 1.5 mu M, respectively.