Patients with seronegative RA have more inflammatory activity compared with patients with seropositive RA in an inception cohort of DMARD-naive patients classified according to the 2010 ACR/EULAR criteria
Patients with seronegative RA have more inflammatory activity compared with patients with seropositive RA in an inception cohort of DMARD-naive patients classified according to the 2010 ACR/EULAR criteria
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DOI：
10.1136/annrheumdis-2015-208873
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发表时间：
2017-02-01
影响因子：
27.4
通讯作者：
Haavardsholm, Espen Andre
中科院分区：
文献类型：
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作者：
Nordberg, Lena Bugge;Lillegraven, Siri;Haavardsholm, Espen Andre
目的比较根据2010年美国风湿病学会（ACR）/欧洲抗风湿联盟（EULAR）标准分类的疾病缓解抗风湿药物（DMARD）初治患者中血清阳性和血清阴性早期类风湿关节炎（RA）的表现。将患者分为血清阳性（阳性类风湿因子（RF）+和/或抗瓜氨酸肽抗体（ACPA）+）或血清阴性（RF-和ACPA-），并比较组间疾病特征。关节超声（US）评分（中位数55 vs 25，p
Objectives To compare the presentation of seropositive and seronegative early rheumatoid arthritis (RA) in disease-modifying antirheumatic drug (DMARD)-naive patients classified according to the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria.Methods All patients had symptom duration from first swollen joint < 2 years and were DMARD naive with an indication for DMARD treatment. Patients were stratified as seropositive (positive rheumatoid factor (RF)+ and/or anticitrullinated peptide antibody (ACPA)+) or seronegative (RF-and ACPA-), and disease characteristics were compared between groups.Results A total of 234 patients were included, and 36 (15.4%) were seronegative. Ultrasonography (US) scores for joints (median 55 vs 25, p