Investigation of the Capture of Magnetic Particles From High-Viscosity Fluids Using Permanent Magnets.
Investigation of the Capture of Magnetic Particles From High-Viscosity Fluids Using Permanent Magnets.
复制标题
DOI：
10.1109/tbme.2015.2458783
复制
发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Arnold DP
中科院分区：
文献类型：
--
作者：
Garraud A;Velez C;Shah Y;Garraud N;Kozissnik B;Yarmola EG;Allen KD;Dobson J;Arnold DP
本文研究了使用小型永磁体捕获高粘度生物流体（如滑液）中的磁性颗粒的实用性。用数值模拟方法预测了磁性粒子向永磁体的运动轨迹。模拟用于确定具有随时间变化的大小和形状的“收集体积”，这决定了在给定时间内可以从流体中捕获的颗粒数量。流体的粘度强烈地影响磁性颗粒向磁铁的速度，因此在给定时间后的收集体积。关于磁体的设计，总体尺寸与磁体形状或宽高比相比，对收集体积的影响最大。数值结果与体外实验结果吻合较好。从长远来看，这项工作旨在促进从高粘度生物流体中收集磁性颗粒-生物标志物偶联物的优化，而无需从患者身上取出液体。
This paper investigates the practicality of using a small, permanent magnet to capture magnetic particles out of high-viscosity biological fluids, such as synovial fluid. Numerical simulations are used to predict the trajectory of magnetic particles toward the permanent magnet. The simulations are used to determine a “collection volume” with a time-dependent size and shape, which determines the number of particles that can be captured from the fluid in a given amount of time. The viscosity of the fluid strongly influences the velocity of the magnetic particles towards the magnet, hence the collection volume after a given time. In regards to the design of the magnet, the overall size is shown to most strongly influence the collection volume in comparison to the magnet shape or aspect ratio. Numerical results showed good agreement with in vitro experimental magnetic collection results. In the long-term, this work aims to facilitate optimization of the collection of magnetic particle-biomarker conjugates from high-viscosity biological fluids without the need to remove the fluid from a patient.