25-hydroxy-26, 26,26,27,27,27-hexafluorovitamin D3: biological activity in the rat.
25-hydroxy-26, 26,26,27,27,27-hexafluorovitamin D3: biological activity in the rat.
复制标题
25-羟基-26,26,26,27,27,27-六氟维生素D3：在大鼠中的生物活性。
DOI：
10.1016/0003-9861(82)90328-9
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发表时间：
1982
影响因子：
3.9
通讯作者：
Ikekawa,N
中科院分区：
文献类型：
--
作者：
Tanaka,Y;Pahuja,DN;Wichmann,JK;DeLuca,HF;Kobayashi,Y;Taguchi,T;Ikekawa,N
Vitamin D-deficient rats given 25-hydroxy-26,26,26,27,27,27-hexafluorovitamin D3have no detectable 24,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3, 25,26-dihydroxyvitamin D3, or 25-hydroxyvitamin D3-26,23-lactone in their blood while the same rats given 25-hydroxyvitamin D3have the expected levels of these compounds in blood. When assayed in the same rats for biological activity, 25-hydroxy-26,26,26,27,27,27-hexafluorovitamin D3was found to be equal to 25-hydroxyvitamin D3in stimulating intestinal calcium transport, bone calcium mobilization, bone mineralization, epiphyseal plate calcification, and elevation of serum inorganic phosphorus. Bilateral nephrectomy eliminates the response of intestine and bone to 25-hydroxy-26,26,26,27,27,27-hexafluorovitamin D3suggesting that this compound must be 1α-hydroxylated to be functional. These results provide evidence that the known functions of vitamin D do not require 26-hydroxylation or oxidation to 25-hydroxyvitamin D3-26,23-lactone.
