Role of reactive oxygen species in the defective regeneration seen in aging muscle.
Role of reactive oxygen species in the defective regeneration seen in aging muscle.
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DOI：
10.1016/j.freeradbiomed.2013.07.008
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发表时间：
2013-12
影响因子：
7.4
通讯作者：
Jackson, Malcolm J.
中科院分区：
文献类型：
--
作者：
Vasilaki, Aphrodite;Jackson, Malcolm J.
肌肉在损伤后成功再生的能力随着年龄的增长而减弱，这似乎是肌肉无力和身体虚弱的主要原因。成功的肌肉再生依赖于再生肌肉的适当再神经支配。神经和肌肉之间的相互作用与年龄相关的变化尚不清楚，但可能在有缺陷的再生中起主要作用。在衰老过程中，有缺陷的氧化还原稳态和神经和肌肉中氧化损伤的积累，可能导致缺陷的再生。这篇综述的目的是总结神经和/或肌肉中异常活性氧（ROS）的产生可能是导致骨骼肌在衰老过程中观察到的再生缺陷的原因。确定衰老过程中骨骼肌中ROS生成的重要性，可能对预防肌肉变性的干预和逆转肌肉质量和功能的年龄相关下降的治疗具有根本性意义。
The ability of muscles to regenerate successfully following damage diminishes with age and this appears to be a major contributor to the development of muscle weakness and physical frailty. Successful muscle regeneration is dependent on appropriate re-innervation of regenerating muscle. Age-related changes in the interactions between nerve and muscle are poorly understood but may play a major role in the defective regeneration. During aging there is defective redox homeostasis and an accumulation of oxidative damage in nerve and muscle that may contribute to defective regeneration. The aim of this review is to summarise the evidence that abnormal Reactive Oxygen Species (ROS) generation in nerve and/or muscle may be responsible for the defective regeneration that contributes to the degeneration of skeletal muscle observed during aging. Identifying the importance of ROS generation in skeletal muscle during aging could have fundamental implications for interventions to prevent muscle degeneration and treatments to reverse the age-related decline in muscle mass and function.
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影响因子：
4.8
作者：
Jang, Youngmok C.;Lustgarten, Michael S.;Van Remmen, Holly
通讯作者：
Van Remmen, Holly
DOI：
10.1007/s00429-004-0429-7
发表时间：
2005-04-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
Borisov, AB;Dedkov, EI;Carlson, BM
通讯作者：
Carlson, BM
影响因子：
5.8
作者：
Kaminski, Jacques;Lancon, Allan;Latruffe, Norbert
通讯作者：
Latruffe, Norbert
影响因子：
3.5
作者：
Aydin, Jan;Andersson, Daniel C.;Westerblad, Hakan
通讯作者：
Westerblad, Hakan
影响因子：
3.3
作者：
Bejma, J;Ji, LL
通讯作者：
Ji, LL