High expressions of CD105 and VEGF in early oral cancer predict potential cervical metastasis
High expressions of CD105 and VEGF in early oral cancer predict potential cervical metastasis
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DOI：
10.1002/jso.20546
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发表时间：
2006-10-01
影响因子：
2.5
通讯作者：
Huang, Chao-Cheng
中科院分区：
文献类型：
--
作者：
Chien, Chih-Yen;Su, Chih-Ying;Huang, Chao-Cheng
背景与目的：尽管择期颈部清扫术已成为大多数头颈部外科医生治疗早期口腔癌的常用方法，但大部分患者术后出现病理性NO。我们的研究旨在评估血管生成因子、血管内皮生长因子（VEGF）和CD105（内皮素）的表达对早期口腔癌临床NO患者颈部转移的预测作用。患者与方法：选取1996年7月至2005年7月间接受手术治疗的176例早期口腔癌患者术前活检标本，进行VEGF和CD105的免疫组化研究。结果：CD105、VEGF高表达分别与淋巴结转移阳性相关（P < 0.001）。CD105的表达与VEGF的表达也显著相关（P < 0.001）。CD105与VEGF高表达预测宫颈转移的敏感性和特异性分别为81.8%和97.7%，高于93.2%和72%。低表达的CD105和VEGF也分别与较高的生存率显著相关（P < 0.001）。结论：在影像学研究的基础上，CD105和VEGF的表达可指导早期口腔癌临床NO颈部的选择性治疗。
Background and Objectives: Although elective neck dissection has become a popular treatment modality for early oral cancer among most head and neck surgeons, a large portion of patients revealed pathological NO postoperatively. Our study is aimed to evaluate the expressions of the angiogenic factors, vascular endothelial growth factor (VEGF), and CD105 (endoglin) on the prediction of neck metastasis for clinical NO patients in early oral cancer.Patients and Methods: Between July 1996 and July 2005, the preoperative biopsy specimens among 176 patients who underwent surgical treatment for early oral cancer were retrieved for the immunohistochemical study for VEGF and CD105.Results: High expressions of CD105 and VEGF significantly correlated with positive nodal metastasis, respectively (P < 0.001). The expression of CD105 also significantly correlated with that of VEGF (P < 0.001). Furthermore, the sensitivity and specificity for prediction of cervical metastasis by high expressions of CD105 versus VEGF were 81.8% and 97.7% versus 93.2% and 72%, respectively. Low expression of CD105 and VEGF also significantly correlated with higher survival rate, respectively (P < 0.001).Conclusions: Besides the image studies, the expressions of both CD105 and VEGF could be useful to guide the elective treatment for clinical NO neck in early oral cancer.