Psychoneurometric operationalization of threat sensitivity: Relations with clinical symptom and physiological response criteria.
Psychoneurometric operationalization of threat sensitivity: Relations with clinical symptom and physiological response criteria.
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DOI：
10.1111/psyp.12512
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发表时间：
2016-03
期刊：
影响因子：
3.7
通讯作者：
Patrick CJ
中科院分区：
文献类型：
--
作者：
Yancey JR;Venables NC;Patrick CJ
NIMH RDoC倡议呼吁通过关注跨多个测量领域（分析单位）调查的生物行为结构，将神经生物学方法和发现纳入精神健康问题的概念。尽管RDoC系统中的构念以“过程术语”（即，作为具有大脑和行为参照物的功能概念）为特征，但这些构念也可以被框定为性格（即，作为个体生物行为功能变化的维度）。本论文聚焦于一个关键的RDoC结构，即急性威胁或“恐惧”，阐述了一种以结构为导向的心理神经测量策略，以个体差异的方式将该结构操作为威胁敏感性（THT+）。利用454名成年参与者的数据，我们实证证明：1) THT+的量表设计可以有效地预测相关的临床问题（即恐惧障碍症状），2)该量表与对厌恶视觉刺激的急性反应性生理指标有可靠的关联，3)反映THT+量表和生理指标交叉的跨域因子可以有效地预测临床和神经生理标准措施。结果说明了心理神经测量方法如何用于创建生物行为特征结构的维度指数，在本例中，THT+可以作为精神病理学和神经生物学领域现象之间的桥梁。参考RDoC倡议和现有的基于报告的心理特征概念，讨论了其意义和未来发展方向。
The NIMH RDoC initiative calls for the incorporation of neurobiological approaches and findings into conceptions of mental health problems through a focus on biobehavioral constructs investigated across multiple domains of measurement (units of analysis). Though the constructs in the RDoC system are characterized in ‘process terms’ (i.e., as functional concepts with brain and behavioral referents), these constructs can also be framed as dispositions (i.e., as dimensions of variation in biobehavioral functioning across individuals). Focusing on one key RDoC construct, acute threat or ‘fear’, the current paper illustrates a construct-oriented psychoneurometric strategy to operationalizing this construct in individual-difference terms—as threat sensitivity (THT+). Utilizing data from 454 adult participants, we demonstrate empirically that: 1) a scale measure of THT+ design to tap general fear/fearlessness predicts effectively to relevant clinical problems (i.e., fear disorder symptoms), 2) this scale measure shows reliable associations with physiological indices of acute reactivity to aversive visual stimuli, and 3) a cross-domain factor reflecting the intersection of scale and physiological indicators of THT+ predicts effectively to both clinical and neurophysiological criterion measures. Results illustrate how the psychoneurometric approach can be used to create a dimensional index of a biobehavioral trait construct, in this case THT+, which can serve as a bridge between phenomena in domains of psychopathology and neurobiology. Implications and future directions are discussed with reference to the RDoC initiative and existing report-based conceptions of psycholological traits.