How to build a myofibril
How to build a myofibril
复制标题
DOI：
10.1007/s10974-005-9016-7
复制
发表时间：
2005-12-01
影响因子：
2.7
通讯作者：
Sanger, Jean M.
中科院分区：
文献类型：
--
作者：
Sanger, Joseph W.;Kang, Songman;Sanger, Jean M.
从其组成蛋白质构建肌原纤维需要许多不同蛋白质的相互作用，其细节尚不清楚。已经提出了几种模型，以提供一个框架，了解新的肌原纤维蛋白及其在肌肉发育过程中的定位的数据不断增加。在这篇文章中，我们讨论了四个目前的模型，试图解释如何组装发生在脊椎动物横纹肌。这些模型假设：（a）作为肌原纤维组装模板的应力纤维样结构，（B）其中肌动蛋白丝和Z带形成独立于A带亚基的亚基的组装，两者随后连接在一起形成肌原纤维，（c）作为肌原纤维前体的前肌原纤维，或（d）在没有任何中间结构的情况下发生的组装。对作者提出的前肌原纤维模型进行了更详细的讨论，因为它可以解释各种不同条件下的肌原纤维发生：卵内、外植体以及心脏和骨骼肌的组织培养研究。
Building a myofibril from its component proteins requires the interactions of many different proteins in a process whose details are not understood. Several models have been proposed to provide a framework for understanding the increasing data on new myofibrillar proteins and their localizations during muscle development. In this article we discuss four current models that seek to explain how the assembly occurs in vertebrate cross-striated muscles. The models hypothesize: (a) stress fiber-like structures as templates for the assembly of myofibrils, (b) assembly in which the actin filaments and Z-bands form subunits independently from A-band subunits, with the two subsequently joined together to form a myofibril, (c) premyofibrils as precursors of myofibrils, or (d) assembly occurring without any intermediary structures. The premyofibril model, proposed by the authors, is discussed in more detail as it could explain myofibrillogenesis under a variety of different conditions: in ovo, in explants, and in tissue culture studies on cardiac and skeletal muscles.